来自植物内生真菌拟盘多毛孢的石竹烷型倍半萜和α-呋喃酮。
Caryophyllene-type sesquiterpenoids and α-furanones from the plant endophytic fungus Pestalotiopsis theae.
机构信息
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100039, China.
State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
出版信息
Chin J Nat Med. 2020 Apr;18(4):261-267. doi: 10.1016/S1875-5364(20)30032-7.
Two new caryophyllene-type sesquiterpenoids, pestathenols A (1) and B (2) and one new α-furanone, pestatheranone A (6), along with five known compounds (3-5, 7 and 8) have been isolated from the crude extract of the plant endophytic fungus Pestalotiopsis theae. Their structures were unambiguously established by extensive spectroscopic analyses. The absolute configuration of the 5,6-diol moiety in 1 was assigned using Snatzke's method. Compounds 1 and 2 showed weak cytotoxicity against HeLa cell line.
从植物内生真菌 Pestalotiopsis theae 的粗提物中分离得到了两个新的石竹烯型倍半萜类化合物 pestathenols A（1）和 B（2），以及一个新的α-呋喃酮 pestatheranone A（6），此外还分离得到了 5 个已知化合物（3-5、7 和 8）。通过广泛的光谱分析，明确了它们的结构。采用 Snatzke 法确定了 1 中 5,6-二醇部分的绝对构型。化合物 1 和 2 对 HeLa 细胞系表现出较弱的细胞毒性。
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