Trepa Monika, Sułkowska-Ziaja Katarzyna, Kała Katarzyna, Muszyńska Bożena
Department of Pharmaceutical Botany, Faculty of Pharmacy, Collegium Medicum, Jagiellonian University, 9 Medyczna St., 30-688 Kraków, Poland.
Doctoral School of Medical and Health Sciences, Collegium Medicum, Jagiellonian University, 16 Św. Łazarza St., 30-530 Kraków, Poland.
Molecules. 2024 Mar 6;29(5):1183. doi: 10.3390/molecules29051183.
Terpenes and their derivatives comprise a diverse group of natural compounds with versatile medicinal properties. This article elucidates the general characteristics of fungal terpenes and terpenoids, encompassing their structure and biogenesis. The focal point of this work involves a comprehensive overview of these compounds, highlighting their therapeutic properties, mechanisms of action, and potential applications in treating specific skin conditions. Numerous isolated terpenes and terpenoids have demonstrated noteworthy anti-inflammatory and anti-microbial effects, rivalling or surpassing the efficacy of currently employed treatments for inflammation or skin infections. Due to their well-documented antioxidant and anti-cancer attributes, these compounds exhibit promise in both preventing and treating skin cancer. Terpenes and terpenoids sourced from fungi display the capability to inhibit tyrosinase, suggesting potential applications in addressing skin pigmentation disorders and cancers linked to melanogenesis dysfunctions. This paper further disseminates the findings of clinical and in vivo research on fungal terpenes and terpenoids conducted thus far.
萜类化合物及其衍生物是一类具有多种药用特性的天然化合物。本文阐述了真菌萜类和萜类化合物的一般特征，包括它们的结构和生物合成。这项工作的重点是对这些化合物进行全面概述，突出它们的治疗特性、作用机制以及在治疗特定皮肤疾病中的潜在应用。许多分离出的萜类和萜类化合物已显示出显著的抗炎和抗菌作用，可与目前用于治疗炎症或皮肤感染的疗法相媲美或更具疗效。由于其有充分记录的抗氧化和抗癌特性，这些化合物在预防和治疗皮肤癌方面都有前景。源自真菌的萜类和萜类化合物具有抑制酪氨酸酶的能力，表明在解决皮肤色素沉着紊乱以及与黑素生成功能障碍相关的癌症方面有潜在应用。本文进一步传播了迄今为止关于真菌萜类和萜类化合物的临床和体内研究结果。
