Cancer Metastasis Alert and Prevention Center, Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, National & Local Joint Biomedical Engineering Research Center on Photodynamic Technologies, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou, Fujian, China.
Integration in Universities of Shandong, Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers, College of Chemistry and Chemical Engineering, Linyi UniversityCollaborative Innovation Center of Tumor Marker Detection Technology, Equipment and Diagnosis-Therapy, Linyi, Shandong, China.
Expert Opin Drug Deliv. 2022 Jun;19(6):707-723. doi: 10.1080/17425247.2022.2083603. Epub 2022 Jun 5.
DNA nanostructures targeting organelles are of great significance for the early diagnosis and precise therapy of human cancers. This review is expected to promote the development of DNA nanostructure-based cancer treatment with organelle-level precision in the future.
In this review, we introduce the different principles for targeting organelles, summarize the progresses in the development of organelle-targeting DNA nanostructures, highlight their advantages and applications in disease treatment, and discuss current challenges and future prospects.
Accurate targeting is a basic problem for effective cancer treatment. However, current DNA nanostructures cannot meet the actual needs. Targeting specific organelles is expected to further improve the therapeutic effect and overcome tumor cell resistance, thereby holding great practical significance for tumor treatment in the clinic. With the deepening of the research on the molecular mechanism of disease development, especially on tumorigenesis and tumor progression, and increasing understanding of the behavior of biological materials in living cells, more versatile DNA nanostructures will be constructed to target subcellular organelles for drug delivery, essentially promoting the early diagnosis of cancers, classification, precise therapy and the estimation of prognosis in the future.
针对细胞器的 DNA 纳米结构对于人类癌症的早期诊断和精确治疗具有重要意义。本综述有望促进未来基于 DNA 纳米结构的细胞器级精确癌症治疗的发展。
在这篇综述中，我们介绍了针对细胞器的不同原理，总结了细胞器靶向 DNA 纳米结构的发展进展，强调了它们在疾病治疗中的优势和应用，并讨论了当前的挑战和未来的前景。
精确靶向是癌症有效治疗的基本问题。然而，目前的 DNA 纳米结构无法满足实际需求。靶向特定细胞器有望进一步提高治疗效果并克服肿瘤细胞耐药性，因此对临床肿瘤治疗具有重要的实际意义。随着对疾病发展分子机制的深入研究，特别是对肿瘤发生和肿瘤进展的研究，以及对生物材料在活细胞中行为的理解不断加深，将构建更多功能多样的 DNA 纳米结构来靶向亚细胞细胞器进行药物输送，从根本上促进癌症的早期诊断、分类、精确治疗和预后评估。
