Allmer Jens
Medical Informatics and Bioinformatics, Hochschule Ruhr West, University of Applied Sciences, Mülheim an der Ruhr, Germany.
Curr Pharm Biotechnol. 2023;24(7):825-831. doi: 10.2174/1570180819666220520124511.
Diseases such as cancer are often defined by dysregulation of gene expression. Noncoding RNAs (ncRNA) such as microRNAs are involved in gene expression and cell-cell communication. Many other ncRNAs exist, such as circular RNAs and small nucleolar RNAs. A wealth of knowledge is available for many ncRNAs, but the information is federated in many databases. A small number of highly complementary ncRNA databases are discussed in this work. Their relevance for cancer research is highlighted, and some of the current problems and limitations are revealed. A central or shared database enforcing community reporting and quality standards is needed in the future. • RNA-seq • Noncoding RNAs • Databases • Data repositories.
诸如癌症之类的疾病通常由基因表达失调所定义。非编码RNA(ncRNA)如微小RNA参与基因表达和细胞间通讯。还存在许多其他ncRNA,如环状RNA和小核仁RNA。关于许多ncRNA已有丰富的知识,但这些信息分散在许多数据库中。本文讨论了少数高度互补的ncRNA数据库。强调了它们与癌症研究的相关性,并揭示了一些当前存在的问题和局限性。未来需要一个强制社区报告和质量标准的中央或共享数据库。•RNA测序•非编码RNA•数据库•数据存储库