Bucholz R W, Carlton A, Holmes R E
Orthop Clin North Am. 1987 Apr;18(2):323-34.
Autografts have consistently outperformed calcium phosphate implants in most experimental models and clinical applications. However, human trials in metaphyseal defects demonstrate comparable results with autograft, hydroxyapatite, and TCP. Diaphyseal fractures and segmental defects represent more challenging problems, with less predictable results achieved with the synthetic bone graft substitutes. Improvements in the pore configuration, mechanical properties, and osteoinductive capacity of these implants should widen their future clinical application.
在大多数实验模型和临床应用中，自体移植始终优于磷酸钙植入物。然而，干骺端缺损的人体试验表明，自体移植、羟基磷灰石和磷酸三钙的结果相当。骨干骨折和节段性缺损是更具挑战性的问题，合成骨移植替代物的效果较难预测。这些植入物在孔隙结构、力学性能和骨诱导能力方面的改进应能扩大其未来的临床应用。
