来自内生真菌SDBR-CMUNKC745的达丁尼亚色酮A，一种罕见的具有与α-内酯稠合的色酮单元的三环聚酮化合物及其对称联苯二聚体达丁尼亚色酮B。
Daldiniaeschsone A, a Rare Tricyclic Polyketide Having a Chromone Unit Fused to a -Lactone and Its Symmetrical Biphenyl Dimer, Daldiniaeschsone B, from an Endophytic Fungus SDBR-CMUNKC745.
作者信息
Wutthiwong Natnicha, Suthiphasilp Virayu, Pintatum Aknarin, Suwannarach Nakarin, Kumla Jaturong, Lumyong Saisamorn, Maneerat Tharakorn, Charoensup Rawiwan, Cheenpracha Sarot, Limtharakul Thunwadee, Pyne Stephen G, Laphookhieo Surat
机构信息
Department of Biology, Faculty of Science, Chiang Mai University, Chiang Mai 50200, Thailand.
Research Center of Microbial Diversity and Sustainable Utilization, Chiang Mai University, Chiang Mai 50200, Thailand.
出版信息
J Fungi (Basel). 2021 May 2;7(5):358. doi: 10.3390/jof7050358.
Daldiniaeschsone A (), a rare tricyclic polyketide having a chromone unit fused to a -lactone and its symmetrical 6,6'-biphenyl dimer, daldiniaeschsone B (), together with three known compounds (-), were isolated from a plant-derived endophytic fungus, SDBR-CMUNKC745. Their structures were elucidated by extensive 1D and 2D NMR spectroscopic data and HRESIMS. All compounds showed -glucosidase inhibitory activity with IC values ranging from 0.16-0.85 mM and compound was the best -glucosidase inhibitory activity (IC = 0.16 mM).
炭团菌酮A（）是一种罕见的三环聚酮化合物，其色酮单元与一个内酯稠合，以及其对称的6,6'-联苯二聚体炭团菌酮B（），与三种已知化合物（-）一起，从一种植物来源的内生真菌SDBR-CMUNKC745中分离得到。它们的结构通过广泛的一维和二维核磁共振光谱数据以及高分辨电喷雾电离质谱得以阐明。所有化合物均表现出α-葡萄糖苷酶抑制活性，IC值范围为0.16 - 0.85 mM，化合物表现出最佳的α-葡萄糖苷酶抑制活性（IC = 0.16 mM）。
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