Xiong Ying, Wintermark Pia
Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China.
Research Institute of the McGill University Health Centre, Montreal, QC, Canada.
Front Cell Neurosci. 2022 May 10;16:879649. doi: 10.3389/fncel.2022.879649. eCollection 2022.
Sildenafil is a recognized treatment for patients suffering from erectile dysfunction and pulmonary hypertension. However, new evidence suggests that it may have a neuroprotective and a neurorestorative role in the central nervous system of both adults and neonates. Phosphodiesterase type 5-the target of sildenafil-is distributed in many cells throughout the body, including neurons and glial cells. This study is a comprehensive review of the demonstrated effects of sildenafil on the brain with respect to its function, extent of injury, neurons, neuroinflammation, myelination, and cerebral vessels.
西地那非是治疗勃起功能障碍和肺动脉高压患者的一种公认药物。然而，新证据表明，它可能在成人和新生儿的中枢神经系统中具有神经保护和神经修复作用。5型磷酸二酯酶——西地那非的靶点——分布于全身许多细胞中，包括神经元和神经胶质细胞。本研究全面综述了西地那非在大脑功能、损伤程度、神经元、神经炎症、髓鞘形成和脑血管方面已证实的作用。
