Fan Linlin, Bass Emily, Klein Hans, Springfield Cassi, Pinkham Amy
School of Behavioral and Brain Sciences, The University of Texas at Dallas, Richardson, TX, United States.
Department of Psychiatry, University of Texas Southwestern Medical School, Dallas, TX, United States.
Schizophr Res Cogn. 2022 May 18;29:100258. doi: 10.1016/j.scog.2022.100258. eCollection 2022 Sep.
Paranoid ideation is a core feature of psychosis and is associated with impaired social functioning. Severity of paranoia can fluctuate across time as symptoms wax and wane; however, no study has systematically investigated how this intra-individual variability in paranoia may relate to social impairments and social functioning.
Fifty-five patients with DSM-5 diagnoses and recent paranoia were followed for up to one year and completed the suspiciousness/persecution section (P6) of the Positive and Negative Symptom Scale (PANSS) on a monthly basis to monitor fluctuations in paranoia. Categorical changes between paranoid and non-paranoid status were monitored and tallied. Participants self-reported current paranoia and anxiety levels as well as social functioning when demonstrating paranoia changes.
Most patients showed changes between paranoid categories (60%). Individuals with no paranoia change showed higher current paranoia and lower independence-competence subscores of the Birchwood Social Functioning Scale (SFS) compared with those with one change. Current paranoia and state anxiety explained significant variance in the prosocial activities subscore of SFS, and importantly, paranoia changes accounted for variance above and beyond these effects. Individuals with higher current paranoia participated less in prosocial activities, however those with higher paranoia variability were more involved in social activities. Similarly, individuals with more paranoia variability demonstrated better overall social functioning as measured by the averaged SFS total score.
Paranoia fluctuation is prevalent across time, and both paranoia severity and variability impact social functioning, in that lower levels of paranoia severity and higher levels of paranoia variability are associated with better interpersonal functioning.
偏执观念是精神病的核心特征,与社会功能受损有关。偏执的严重程度会随着症状的消长而随时间波动;然而,尚无研究系统地调查这种偏执的个体内变异性如何与社会障碍和社会功能相关。
对55名符合《精神疾病诊断与统计手册》第5版诊断标准且近期有偏执观念的患者进行了长达一年的随访,每月完成阳性和阴性症状量表(PANSS)的猜疑/迫害分量表(P6)以监测偏执的波动情况。监测并记录偏执状态与非偏执状态之间的分类变化。参与者在出现偏执变化时自我报告当前的偏执和焦虑水平以及社会功能。
大多数患者在偏执类别之间出现了变化(60%)。与有一次变化的患者相比,没有偏执变化的个体当前的偏执程度更高,且在伯奇伍德社会功能量表(SFS)的独立能力子量表上得分更低。当前的偏执和状态焦虑解释了SFS亲社会活动子量表中的显著差异,重要的是,偏执变化在这些影响之外还解释了额外的差异。当前偏执程度较高的个体参与亲社会活动较少,然而,偏执变异性较高的个体更多地参与社会活动。同样,用SFS总分平均值衡量,偏执变异性较高的个体总体社会功能更好。
偏执波动在一段时间内普遍存在,偏执的严重程度和变异性都会影响社会功能,即较低的偏执严重程度和较高的偏执变异性与更好的人际功能相关。