不同年龄的中度新冠肺炎男性和女性患者的超氧化物歧化酶活性
Superoxide Dismutase Activity in Male and Female Patients of Different Age with Moderate COVID-19.
作者信息
Semenova N V, Rychkova L V, Darenskaya M A, Kolesnikov S I, Nikitina O A, Petrova A G, Vyrupaeva E V, Kolesnikova L I
机构信息
Research Center for Family Health and Human Reproduction Problems, Irkutsk, Russia.
出版信息
Bull Exp Biol Med. 2022 May;173(1):51-53. doi: 10.1007/s10517-022-05491-6. Epub 2022 May 27.
Abstract
The study involved 271 patients (132 men and 139 women) with moderate COVID-19. Superoxide dismutase (SOD) activity in erythrocytes was measured spectrophotometrically. In total group of patients (divided into age groups of 18-35, 36-45, 46-60, and 61-90 years), higher SOD activity was found in the 18-35 age group in comparison with the groups 46-60 years (p<0.01) and 61-90 years (p<0.05). Then, the groups were additionally divided by sex. In men, no differences in enzyme activity were found between the age groups. In women of early reproductive age, SOD activity was higher than in groups 36-45, 46-60, and 61-90 years. The sex differences consisted in higher SOD activity in women aged 18-35 years in comparison with men of this age. These data should be taken into account when choosing the tactics of therapy for patients with moderate COVID-19 course.
摘要
该研究纳入了271例中度新型冠状病毒肺炎患者（132例男性和139例女性）。采用分光光度法测定红细胞中超氧化物歧化酶（SOD）活性。在患者总组（分为18 - 35岁、36 - 45岁、46 - 60岁和61 - 90岁年龄组）中，发现18 - 35岁年龄组的SOD活性高于46 - 60岁组（p<0.01）和61 - 90岁组（p<0.05）。然后，这些组再按性别进一步划分。在男性中，各年龄组之间未发现酶活性差异。在育龄早期女性中，SOD活性高于36 - 45岁、46 - 60岁和61 - 90岁组。性别差异在于18 - 35岁女性的SOD活性高于该年龄段男性。在为中度新型冠状病毒肺炎病程患者选择治疗策略时应考虑这些数据。
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