N. P. Ogarev National Research Mordovia State University, Saransk, Mordovia Republic, Russia.
S. V. Katkov Republican Clinical Hospital, Saransk, Mordovia Republic, Russia.
Bull Exp Biol Med. 2022 May;173(1):46-50. doi: 10.1007/s10517-022-05490-7. Epub 2022 May 27.
Morphological and functional characteristics of erythrocytes, hemoglobin, and erythropoietin level in the venous blood were evaluated by laser interference microscopy, Raman spectroscopy with a short-focus extreme aperture lens monochromator, and by ELISA, respectively, in 30 patients with verified moderate COVID-19 at the time of hospitalization and 30 healthy volunteers. The patients whose course of COVID-19 has worsened to critical by day 5 had already had lower (p<0.001) indicators at the time of hospitalization such as the area and thickness of erythrocytes, the hemoglobin distribution and packing density, hemoglobin conformation index (I/I)/(I/I) reflecting its oxygen affinity, and blood erythropoietin content. Our findings suggest that these characteristics of erythrocytes, hemoglobin, and erythropoietin can serve as potential predictors of COVID-19 aggravation in hospitalized patients.
通过激光干涉显微镜、带有短焦极限孔径透镜单色仪的拉曼光谱和 ELISA，分别评估了 30 名确诊中度 COVID-19 住院患者和 30 名健康志愿者静脉血中红细胞、血红蛋白和促红细胞生成素水平的形态和功能特征。在第 5 天病情恶化至危重症的 COVID-19 患者，在住院时就已经出现了较低的指标，如红细胞面积和厚度、血红蛋白分布和堆积密度、反映其氧亲和力的血红蛋白构象指数 (I/I)/(I/I)，以及血液促红细胞生成素含量。我们的研究结果表明，这些红细胞、血红蛋白和促红细胞生成素的特征可以作为住院患者 COVID-19 恶化的潜在预测指标。
