Garrabou Glòria, Hernández Ana Sandra, Guitart-Mampel Mariona, Escalada-Casellas Elena, Malats-Revelles Gemma, Castro-Barquero Sara, Ruiz-León Ana María, Vellvé Kilian, Casas Rosa, Cardellach Francesc, Crispi Fàtima, García-García Francesc Josep
Muscle Research and Mitochondrial Function Laboratory, Cellex-IDIBAPS, Faculty of Medicine and Health Sciences, University of Barcelona, 08036 Barcelona, Spain.
Internal Medicine Unit, Medicine Department, Hospital Clínic of Barcelona, 08036 Barcelona, Spain.
Antioxidants (Basel). 2022 Apr 25;11(5):833. doi: 10.3390/antiox11050833.
Intrauterine growth restriction (IUGR) affects 5-10% of newborns and increases the risks of intrauterine demise, neonatal morbidity, and death. In their recent publication, Yeste et al. found the benefits of hydroxytyrosol supplementation on brain remodeling from an IUGR pig model. Additionally, we found a significant decrease in phenolic alcohol (tyrosol and hydroxytyrosol) intake in IUGR pregnant women. Altogether, these findings support the notion that dietetic interventions, through supplementation but mostly via a balanced diet, can ameliorate IUGR complications. Furthermore, diet intervention combined with early biomarkers may allow clinicians to eventually anticipate IUGR diagnosis and help avoid one of the most frequent causes of newborn mortality and morbidity.
宫内生长受限（IUGR）影响5%至10%的新生儿，并增加宫内死亡、新生儿发病和死亡的风险。在他们最近发表的文章中，耶斯特等人从IUGR猪模型中发现了补充羟基酪醇对大脑重塑的益处。此外，我们发现IUGR孕妇的酚类醇（酪醇和羟基酪醇）摄入量显著降低。总之，这些发现支持了这样一种观点，即饮食干预，通过补充剂但主要是通过均衡饮食，可以改善IUGR并发症。此外，饮食干预与早期生物标志物相结合，可能使临床医生最终能够预测IUGR诊断，并有助于避免新生儿死亡和发病的最常见原因之一。
