Cortegoso Valdivia Pablo, Skonieczna-Żydecka Karolina, Elosua Alfonso, Sciberras Martina, Piccirelli Stefania, Rullan Maria, Tabone Trevor, Gawel Katarzyna, Stachowski Adam, Lemiński Artur, Marlicz Wojciech, Fernández-Urién Ignacio, Ellul Pierre, Spada Cristiano, Pennazio Marco, Toth Ervin, Koulaouzidis Anastasios
Gastroenterology and Endoscopy Unit, University Hospital of Parma, University of Parma, 43126 Parma, Italy.
Department of Biochemical Sciences, Pomeranian Medical University, 71-460 Szczecin, Poland.
Diagnostics (Basel). 2022 Apr 28;12(5):1105. doi: 10.3390/diagnostics12051105.
Capsule endoscopy (CE) has become a widespread modality for non-invasive evaluation of the gastrointestinal (GI) tract, with several CE models having been developed throughout the years. The aim of this systematic review and meta-analysis is to evaluate performance measures such as completion, detection and retention rates of CE.
Literature through to August 2021 was screened for articles regarding all capsule types: small bowel, double-headed capsule for the colon or PillCamCrohn's capsule, magnetically-controlled capsule endoscopy, esophageal capsule and patency capsule. Primary outcomes included detection rate (DR), completion rate (CR) and capsule retention rate (RR). DR, CR and RR were also analyzed in relation to indications such as obscure GI bleeding (OGIB), known/suspected Crohn's disease (CD), celiac disease (CeD), neoplastic lesions (NL) and clinical symptoms (CS).
328 original articles involving 86,930 patients who underwent CE were included. OGIB was the most common indication (n = 44,750), followed by CS (n = 17,897), CD (n = 11,299), NL (n = 4989) and CeD (n = 947). The most used capsule type was small bowel CE in 236 studies. DR, CR and RR for all indications were 59%, 89.6% and 2%, respectively. According to specific indications: DR were 55%, 66%, 63%, 52% and 62%; CR were 90.6%, 86.5%, 78.2%, 94% and 92.8%; and RR were 2%, 4%, 1%, 6% and 2%.
Pooled DR, CR and RR are acceptable for all capsule types. OGIB is the most common indication for CE. Technological advancements have expanded the scope of CE devices in detecting GI pathology with acceptable rates for a complete examination.
胶囊内镜检查（CE）已成为用于胃肠道（GI）无创评估的一种广泛应用的方式，多年来已开发出多种CE型号。本系统评价和荟萃分析的目的是评估CE的完成率、检测率和滞留率等性能指标。
筛选截至2021年8月的文献，查找有关所有胶囊类型的文章：小肠胶囊、用于结肠的双头胶囊或PillCamCrohn's胶囊、磁控胶囊内镜、食管胶囊和通畅性胶囊。主要结局包括检测率（DR）、完成率（CR）和胶囊滞留率（RR）。还针对诸如不明原因消化道出血（OGIB）、已知/疑似克罗恩病（CD）、乳糜泻（CeD）、肿瘤性病变（NL）和临床症状（CS）等适应证分析了DR、CR和RR。
纳入了328篇涉及86930例接受CE检查患者的原始文章。OGIB是最常见的适应证（n = 44750），其次是CS（n = 17897）、CD（n = 11299）、NL（n = 4989）和CeD（n = 947）。在236项研究中最常用的胶囊类型是小肠CE。所有适应证的DR、CR和RR分别为59%、89.6%和2%。根据具体适应证：DR分别为55%、66%、63%、52%和62%；CR分别为90.6%、86.5%、78.2%、94%和92.8%；RR分别为2%、4%、1%、6%和2%。
所有胶囊类型的汇总DR、CR和RR均可接受。OGIB是CE最常见的适应证。技术进步扩大了CE设备在检测胃肠道病变方面的范围，完整检查的成功率可接受。
