Latomme Julie, Calders Patrick, Van Waelvelde Hilde, Mariën Tineke, De Craemer Marieke
Department of Movement and Sports Sciences, Ghent University, 9000 Ghent, Belgium.
Department of Rehabilitation Sciences and Physiotherapy, Ghent University, 9000 Ghent, Belgium.
Children (Basel). 2022 Apr 22;9(5):596. doi: 10.3390/children9050596.
Physical activity (PA) can improve children's executive functioning (EF), which might be caused by increased levels of brain-derived neurotrophic factor (BDNF). This study investigated whether acute and/or chronic PA leads to increased BDNF levels and enhanced EF in children. In total, 47 children (mean age 9.69 ± 0.60; 46.8% boys) participated. Children performed a maximal exercise test to measure acute PA. Before and after, BDNF was collected and EF was measured. Chronic PA was proxy-reported. Repeated Measures ANOVAs were performed to study the effect of acute PA on BDNF and EF. Mediation analyses were performed to investigate the mediation effect of BDNF on the association between chronic PA and BDNF. A borderline significant effect of acute PA on BDNF was found (F = 3.32, = 0.075) with an increase in BDNF (+29.58 pg/mL) after acute PA. A significant effect was found for performance on inhibition tasks (Flanker (accuracy +5.67%, = 0.034) and Go/No-Go (+0.15%, = 0.022)). No effect of acute PA was found on the EF outcomes. No significant correlation between chronic PA and EFs nor BDNF was found. Acute PA might increase BDNF and improve some EFs (i.e., inhibition) in children. Chronic PA was not associated with EF nor BDNF. NCT02503579.
体育活动（PA）可以改善儿童的执行功能（EF），这可能是由脑源性神经营养因子（BDNF）水平升高所致。本研究调查了急性和/或慢性PA是否会导致儿童BDNF水平升高和EF增强。共有47名儿童（平均年龄9.69±0.60岁；46.8%为男孩）参与。儿童进行了最大运动测试以测量急性PA。测试前后，收集BDNF并测量EF。慢性PA通过代理报告。采用重复测量方差分析来研究急性PA对BDNF和EF的影响。进行中介分析以研究BDNF对慢性PA与EF之间关联的中介作用。发现急性PA对BDNF有边缘显著效应（F = 3.32，P = 0.075），急性PA后BDNF增加（+29.58 pg/mL）。在抑制任务表现方面发现显著效应（Flanker任务（准确率 +5.67%，P = 0.034）和Go/No - Go任务（+0.15%，P = 0.022））。未发现急性PA对EF结果有影响。未发现慢性PA与EFs以及BDNF之间存在显著相关性。急性PA可能会增加儿童的BDNF并改善一些EF（即抑制功能）。慢性PA与EF和BDNF均无关联。临床试验注册号：NCT02503579。
