Department of Human Health Care, Gyeongsang National University, Jinju 52725, Korea.
School of Health and Kinesiology, University of Nebraska at Omaha, Omaha, NE 68182, USA.
Int J Mol Sci. 2022 May 15;23(10):5517. doi: 10.3390/ijms23105517.
Advanced maternal age (AMA) denotes an age of ≥35 years during the time of delivery. Maternal metabolism affects the offspring's physical and neurological development as well as their cognitive function. This study aimed to elucidate the effects of exercise training among old female animals on the cognitive function, hippocampal neuroplasticity, mitochondrial function, and apoptosis in the offspring. We found that the offspring of mothers with AMA without exercise training had decreased spatial learning and memory, brain-derived neurotrophic factor (BDNF) and postsynaptic density protein 95 (PSD-95) protein levels, neurogenesis, and mitochondrial function, as well as hippocampal cell death. Contrastingly, offspring of mothers with AMA with exercise training showed improved spatial learning, memory, hippocampal neuroplasticity, and mitochondrial function. These findings indicate that despite the AMA, increasing fitness through exercise significantly contributes to a positive prenatal environment for fetuses. The maternal exercises augmented the hippocampal levels of BDNF, which prevents decreased cognitive function in the offspring of mothers with AMA.
高龄产妇（AMA）是指分娩时年龄≥35 岁。母体代谢会影响后代的身体和神经发育以及认知功能。本研究旨在阐明老年雌性动物的运动训练对后代认知功能、海马神经可塑性、线粒体功能和细胞凋亡的影响。我们发现，未经运动训练的 AMA 产妇的后代空间学习和记忆能力下降，脑源性神经营养因子（BDNF）和突触后密度蛋白 95（PSD-95）蛋白水平、神经发生和线粒体功能以及海马细胞死亡。相比之下，AMA 产妇进行运动训练的后代空间学习、记忆、海马神经可塑性和线粒体功能得到改善。这些发现表明，尽管存在 AMA，但通过运动提高健康水平对胎儿的产前环境有积极影响。母体运动增加了 BDNF 在海马中的水平，防止了 AMA 产妇后代认知功能下降。
