Kim Tae-Woon, Park Sang-Seo, Park Hye-Sang
Department of Human Health Care, Gyeongsang National University, Jinju, Korea.
School of Health and Kinesiology, University of Nebraska at Omaha, Omaha, NE, USA.
J Exerc Rehabil. 2022 Jun 27;18(3):155-161. doi: 10.12965/jer.2244262.131. eCollection 2022 Jun.
For humans, maternal old age means the age of 35 or older at the time of childbirth. Maternal metabolism not only affects the cognitive function of the offspring, but also affects their physical and neurological development. This study aims to elucidate the effects of exercise training on spatial learning memory, neurogenesis, and apoptosis in the off-spring of old mice. Using mice, the offspring of old mothers showed impaired spatial learning memory, decreased brain-derived neurotrophic factor and postsynaptic density protein 95 levels, suppressed neurogenesis, and increased hippocampal apoptotic cell death. In contrast, the offspring of the old mothers had improved spatial learning memory, increased brain-derived neurotrophic factor and postsynaptic density protein 95 levels, increased neurogenesis, and decreased hippocampal apoptotic cell death when they received exercise training. The present results indicate that there is apparent spatial learning memory impairment among the offspring of old mothers, but by contrast, exercise can ameliorate spatial learning memory impairment. Exercise can be an effective countermeasure against memory decline in the offspring of old mothers.
对人类而言，高龄产妇是指分娩时年龄在35岁及以上的女性。母体代谢不仅会影响后代的认知功能，还会影响其身体和神经发育。本研究旨在阐明运动训练对老年小鼠后代空间学习记忆、神经发生和细胞凋亡的影响。以小鼠为实验对象，老年母鼠的后代表现出空间学习记忆受损、脑源性神经营养因子和突触后密度蛋白95水平降低、神经发生受抑制以及海马体凋亡细胞死亡增加。相比之下，老年母鼠的后代在接受运动训练后，空间学习记忆得到改善、脑源性神经营养因子和突触后密度蛋白95水平升高、神经发生增加且海马体凋亡细胞死亡减少。目前的研究结果表明，老年母鼠的后代存在明显的空间学习记忆障碍，但运动可以改善这种障碍。运动可能是预防老年母鼠后代记忆衰退的有效对策。
