Zopfiellasins A-D, Two Pairs of Epimeric Cytochalasins from Kiwi-Associated Fungus sp. and Their Antibacterial Assessment.

In our continuous search for antibacterial agents against pv. (Psa) from kiwi-associated fungi, two pairs of epimeric cytochalasins, zopfiellasins A-D (-), were characterized from the fungus sp. The structures were established on the basis of spectroscopic data analysis, while the absolute configurations were determined by single-crystal X-ray diffraction. Compounds and exhibited antibacterial activity against Psa with MIC values of 25 and 50 μg/mL, respectively. This is the first report of anti-Psa activity of cytochalasin derivatives.