Chen Yu-Chen, Liang Yin-Chi, Ho Shuo-Jung, Chen Hao-Wei, Juan Yung-Shun, Tsai Wei-Chung, Huang Shu-Pin, Lee Jung-Ting, Liu Yu-Peng, Kao Chung-Yao, Lin Yen-Ko, Long Cheng-Yu, Wu Meng-Ni, Chen Chao-Ju, Wu Wen-Jeng
Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
J Clin Med. 2022 May 12;11(10):2736. doi: 10.3390/jcm11102736.
We investigated the storage lower urinary tract symptoms (LUTS) before and after the first dose of coronavirus disease 2019 (COVID-19) vaccine and the association between pre-vaccinated overactive bladder (OAB) and the worsening of storage LUTS following COVID-19 vaccination. This cross-sectional study in a third-level hospital in Taiwan used the validated pre- and post-vaccinated Overactive Bladder Symptom Score (OABSS). Diagnosis of OAB was made using pre-vaccinated OABSS. The deterioration of storage LUTS was assessed as the increased score of OABSS following vaccination. Of 889 subjects, up to 13.4% experienced worsened storage LUTS after vaccination. OAB was significantly associated with an increased risk of worsening urinary urgency (p = 0.030), frequency (p = 0.027), and seeking medical assistance due to urinary adverse events (p < 0.001) after vaccination. The OAB group faced significantly greater changes in OABSS-urgency (p = 0.003), OABSS-frequency (p = 0.025), and total OABSS (p = 0.014) after vaccination compared to those observed in the non-OAB group. Multivariate regression revealed that pre-vaccinated OAB (p = 0.003) was a risk for the deterioration of storage LUTS. In conclusion, storage LUTS may deteriorate after vaccination. OAB was significantly associated with higher risk and greater changes in worsening storage LUTS. Storage LUTS should be closely monitored after COVID-19 vaccination, especially in those OAB patients.
我们调查了2019冠状病毒病（COVID-19）疫苗首剂接种前后的储尿期下尿路症状（LUTS），以及接种疫苗前的膀胱过度活动症（OAB）与COVID-19疫苗接种后储尿期LUTS恶化之间的关联。这项在台湾一家三级医院开展的横断面研究使用了经过验证的接种疫苗前后的膀胱过度活动症症状评分（OABSS）。OAB的诊断采用接种疫苗前的OABSS。储尿期LUTS的恶化通过接种疫苗后OABSS评分的增加来评估。在889名受试者中，高达13.4%的人在接种疫苗后出现储尿期LUTS恶化。OAB与接种疫苗后尿急加重风险增加（p = 0.030）、尿频加重风险增加（p = 0.027）以及因泌尿不良事件寻求医疗帮助的风险增加（p < 0.001）显著相关。与非OAB组相比，OAB组在接种疫苗后OABSS-尿急评分（p = 0.003）、OABSS-尿频评分（p = 0.025）和总OABSS评分（p = 0.014）的变化明显更大。多变量回归显示，接种疫苗前的OAB（p = 0.003）是储尿期LUTS恶化的一个风险因素。总之，接种疫苗后储尿期LUTS可能会恶化。OAB与储尿期LUTS恶化的较高风险和更大变化显著相关。COVID-19疫苗接种后应密切监测储尿期LUTS情况，尤其是在那些OAB患者中。
