Fericean Roxana Manuela, Citu Cosmin, Manolescu Diana, Rosca Ovidiu, Bratosin Felix, Tudorache Emanuela, Oancea Cristian
Department XIII, Discipline of Infectious Diseases, "Victor Babes" University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania.
Doctoral School, ''Victor Babes'' University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania.
J Clin Med. 2022 May 21;11(10):2916. doi: 10.3390/jcm11102916.
There are few data on the dynamics of SARS-CoV-2 viral manifestations in obese and overweight persons during each of the five waves that occurred in Romania during the last two years. As such, the purpose of this research was to characterize the variance in case severity, symptomatology, ICU hospitalizations, and mortality among overweight and obese individuals infected with the SARS-CoV-2 virus. We included 250 overweight and obese patients admitted to hospital with COVID-19, where 50 patients were selected from each of the five pandemic waves that existed in Romania until March 2022. A total of 113 patients with normal body mass index were included in the study. They were matched with overweight and obese patients by age, gender, and cardiovascular comorbidities to avoid the effect of confounding factors. Between the five waves of the COVID-19 pandemic in Romania, the present investigation found substantial changes in overweight and obese patient features. Obesity increases the risk of hospitalization, severe complications, and mortality from COVID-19. However, this unique demographic is disproportionately affected by obesity-related comorbidities, which contribute to these adverse outcomes. We advocate for the development of new guiding principles for the formulation of healthcare strategies aimed at high-prevalence special populations such as overweight and obese individuals, while also promoting pandemic containment and avoiding the recurrence of pandemic waves with the same guidelines that proved detrimental in terms of economic and human life loss.
关于过去两年罗马尼亚出现的五波新冠疫情期间，肥胖和超重人群中新冠病毒表现的动态数据很少。因此，本研究的目的是描述感染新冠病毒的超重和肥胖个体在病例严重程度、症状、重症监护病房住院情况及死亡率方面的差异。我们纳入了250名因新冠肺炎住院的超重和肥胖患者，其中50名患者选自罗马尼亚截至2022年3月出现的五波疫情中的每一波。该研究共纳入了113名体重指数正常的患者。通过年龄、性别和心血管合并症将他们与超重和肥胖患者进行匹配，以避免混杂因素的影响。在罗马尼亚新冠肺炎疫情的五波期间，本调查发现超重和肥胖患者的特征有显著变化。肥胖会增加新冠肺炎住院、严重并发症和死亡的风险。然而，这一独特人群受肥胖相关合并症的影响尤为严重，这些合并症导致了这些不良后果。我们主张制定新的指导原则，以制定针对超重和肥胖等高流行特殊人群的医疗保健策略，同时促进疫情防控，并避免因那些在经济和生命损失方面已证明有害的相同指导方针导致疫情浪潮再次出现。
