Pisoni Serena, Marrachelli Vannina G, Morales Jose M, Maestrini Sabrina, Di Blasio Anna M, Monleón Daniel
Department of Pathology, Medicine and Odontology Faculty, University of Valencia, 46010 Valencia, Spain.
Department of Physiology, Medicine and Odontology Faculty, University of Valencia, 46010 Valencia, Spain.
Metabolites. 2022 May 6;12(5):419. doi: 10.3390/metabo12050419.
Adult morbid obesity is defined as abnormal or excessive fat accumulation, mostly resulting from a long-term unhealthy lifestyle. Between 10% and 30% of people with obesity exhibit low cardiometabolic risk. The metabolic syndrome has been suggested as an indicator of obesity-related metabolic dysregulation. Although the prevalence of obesity does not seem to be sex-related and metabolic syndrome occurs at all ages, in the last few years, sex-specific differences in the pathophysiology, diagnosis, and treatment of metabolic syndrome have received attention. The aim of this study was to determine the prevalence of metabolic syndrome and its components in different sex and age groups in people with metabolic unhealthy obesity and to compare them with people with metabolic healthy obesity. We analyzed the metabolome in 1350 well-phenotyped morbidly obese individuals and showed that there is a strong sex-dependent association of metabolic syndrome with circulating metabolites. Importantly, we demonstrated that metabolic dysregulation in women and men with severe obesity and metabolic syndrome is age-dependent. The metabolic profiles from our study showed age-dependent sex differences in the impact of MetS which are consistent with the cardiometabolic characterization. Although there is common ground for MetS in the metabolome of severe obesity, men older than 54 are affected in a more extensive and intensive manner. These findings strongly argue for more studies aimed at unraveling the mechanisms that underlie this sex-specific metabolic dysregulation in severe obesity. Moreover, these findings suggest that women and men might benefit from differential sex and age specific interventions to prevent the adverse cardiometabolic effects of severe obesity.
成人病态肥胖被定义为异常或过多的脂肪堆积，主要是由长期不健康的生活方式导致的。10%至30%的肥胖者表现出低心血管代谢风险。代谢综合征被认为是肥胖相关代谢失调的一个指标。尽管肥胖的患病率似乎与性别无关，且代谢综合征在各年龄段均有发生，但在过去几年中，代谢综合征在病理生理学、诊断和治疗方面的性别差异受到了关注。本研究的目的是确定代谢不健康肥胖人群中不同性别和年龄组代谢综合征及其组分的患病率，并将其与代谢健康肥胖人群进行比较。我们分析了1350名表型良好的病态肥胖个体的代谢组，结果表明代谢综合征与循环代谢物之间存在强烈的性别依赖性关联。重要的是，我们证明了严重肥胖和代谢综合征患者中，女性和男性的代谢失调存在年龄依赖性。我们研究的代谢谱显示，代谢综合征的影响存在年龄依赖性的性别差异，这与心血管代谢特征一致。尽管严重肥胖的代谢组中存在代谢综合征的共同特征，但54岁以上的男性受到的影响更为广泛和强烈。这些发现有力地支持了开展更多研究以揭示严重肥胖中这种性别特异性代谢失调背后机制的观点。此外，这些发现表明，女性和男性可能会从针对性别和年龄的不同干预措施中受益，以预防严重肥胖的不良心血管代谢影响。
