Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
National Institutes for Food and Drug Control, Beijing 102627, China.
Molecules. 2022 May 13;27(10):3133. doi: 10.3390/molecules27103133.
(L.) Britt., a medicinal herb and edible plant, is very popular among East Asian countries. The perilla leaves, stems and seeds can be used as traditional medicines and foods. Polycyclic aromatic hydrocarbons (PAHs) and halogenated PAHs (HPAHs) are organic pollutants that are widely present in the environment, such as in water, air and soil, and are harmful to humans. In this study, the contents of 16 PAHs and 4 HPAHs in perilla leaves, stems and seeds were determined by gas chromatography tandem mass spectrometry (GC-MS). A total of 12 PAHs were detected in all samples, and no HPAHs were detected. The total contents of PAHs in perilla leaves, stems and seeds varied from 41.93 to 415.60 ng/g, 7.02 to 51.52 ng/g and 15.24 to 180.00 ng/g, respectively. The statistical analyses showed that there were significant differences in the distribution of PAHs in perilla leaves, stems and seeds. On the basis of the toxic equivalent quantity (TEQ) and incremental lifetime cancer risk (ILCR) model, the cancer risks of the intake of perilla leaves, stems and seeds were assessed to be from 3.30 × 10 to 2.11 × 10, 5.52 × 10 to 5.50 × 10 and 1.20 × 10 to 1.41 × 10, respectively. These were lower than 10 (the priority risk level of the EPA) and suggested that there may be almost no cancer risk from the intake of these traditional Chinese medicines (TCMs).
（L.）Britt.，一种药草和食用植物，在东亚国家非常受欢迎。其叶子、茎和种子可作为传统药物和食品。多环芳烃（PAHs）和卤代多环芳烃（HPAHs）是广泛存在于水、空气和土壤等环境中的有机污染物，对人体有害。本研究采用气相色谱串联质谱法（GC-MS）测定了紫苏叶、茎和种子中 16 种 PAHs 和 4 种 HPAHs 的含量。在所有样品中均检测到 12 种 PAHs，未检测到 HPAHs。紫苏叶、茎和种子中 PAHs 的总含量分别为 41.93415.60ng/g、7.0251.52ng/g 和 15.24180.00ng/g。统计分析表明，紫苏叶、茎和种子中 PAHs 的分布存在显著差异。基于毒性等效系数（TEQ）和增量终生癌症风险（ILCR）模型，评估了紫苏叶、茎和种子摄入的癌症风险，分别为 3.30×102.11×10、5.52×105.50×10和 1.20×101.41×10。这些都低于 10（美国环保署的优先风险水平），表明从这些中药（TCMs）摄入可能几乎没有癌症风险。
