College of Pharmacy, Ningxia Medical University, Yinchuan 750004, China.
Key Laboratory of Ningxia Ethnomedicine Modernization, Ministry of Education, Ningxia Medical University, Yinchuan 750004, China.
Molecules. 2023 Aug 4;28(15):5883. doi: 10.3390/molecules28155883.
is an annual herb of the Labiatae family and is widely grown in several countries in Asia. is a plant that is used medicinally in its entirety, as seen in its subdivision into perilla seeds, perilla stalks, and perilla leaves, which vary more markedly in their chemical composition. Several studies have shown that has a variety of pharmacological effects, including anti-inflammatory, antibacterial, detoxifying, antioxidant, and hepatoprotective. In the absence of a review of for the treatment of cancer. This review provides an overview of the chemical composition and molecular mechanisms of for cancer treatment. It was found that the main active components of producing cancer therapeutic effects were perilla aldehyde (PAH), rosmarinic acid (Ros A), lignan, and isoestrogen (IK). In addition to these, extracts of the leaves and fruits of are also included. Among these, perilla seed oil (PSO) has a preventive effect against colorectal cancer due to the presence of omega-3 polyunsaturated fatty acids. This review also provides new ideas and thoughts for scientific innovation and clinical applications related to .
紫苏是唇形科一年生草本植物，在亚洲多个国家广泛种植。紫苏作为药用植物，全草入药，紫苏子、紫苏梗、紫苏叶三个部位化学成分差异显著。已有多项研究表明，紫苏具有多种药理作用，包括抗炎、抗菌、解毒、抗氧化、保肝等。目前尚未检索到紫苏治疗癌症的相关综述。本综述概述了紫苏治疗癌症的化学成分和分子机制。研究发现，紫苏发挥抗癌作用的主要活性成分包括紫苏醛（PAH）、迷迭香酸（Ros A）、木脂素和异黄酮（IK）。此外，紫苏的叶和果实提取物也具有抗癌活性，其中紫苏籽油（PSO）由于含有ω-3 多不饱和脂肪酸，对结直肠癌具有预防作用。本综述为紫苏的科学创新和临床应用提供了新的思路和启示。
