Machado Mónica, Oliveira Alexandra M L, Silva Gabriela A, Bitoque Diogo B, Tavares Ferreira Joana, Pinto Luís Abegão, Ferreira Quirina
Instituto de Telecomunicações, Avenida Rovisco Pais, 1049-001 Lisbon, Portugal.
iNOVA4Health, CEDOC Chronic Diseases Research Center, NOVA Medical School, Universidade Nova de Lisboa, Campo Mártires da Pátria 130, 1169-056 Lisbon, Portugal.
Nanomaterials (Basel). 2022 May 10;12(10):1624. doi: 10.3390/nano12101624.
Graphene is the material elected to study molecules and monolayers at the molecular scale due to its chemical stability and electrical properties. The invention of scanning tunneling microscopy has deepened our knowledge on molecular systems through imaging at an atomic resolution, and new possibilities have been investigated at this scale. Interest on studies on biomolecules has been demonstrated due to the possibility of mimicking biological systems, providing several applications in nanomedicine: drug delivery systems, biosensors, nanostructured scaffolds, and biodevices. A breakthrough came with the synthesis of molecular systems by stepwise methods with control at the atomic/molecular level. This article presents a review on self-assembled monolayers of biomolecules on top of graphite with applications in biodevices. Special attention is given to porphyrin systems adsorbed on top of graphite that are able to anchor other biomolecules.
由于石墨烯的化学稳定性和电学性质，它被选为在分子尺度上研究分子和单分子层的材料。扫描隧道显微镜的发明通过原子分辨率成像加深了我们对分子系统的认识，并且在这个尺度上已经研究了新的可能性。由于有可能模拟生物系统，对生物分子研究的兴趣已经得到证明，这在纳米医学中有多种应用：药物递送系统、生物传感器、纳米结构支架和生物装置。通过在原子/分子水平上进行控制的逐步方法合成分子系统带来了突破。本文综述了石墨表面生物分子自组装单分子层及其在生物装置中的应用。特别关注吸附在石墨表面的能够锚定其他生物分子的卟啉系统。
