Guard Jean, Rivers Adam R, Vaughn Justin N, Rothrock Michael J, Oladeinde Adelumola, Shah Devendra H
US Department of Agriculture, US National Poultry Research Center, Athens, GA 30605, USA.
US Department of Agriculture, Genomics and Bioinformatics Research, Gainesville, FL 32608, USA.
Microorganisms. 2021 Oct 1;9(10):2075. doi: 10.3390/microorganisms9102075.
Adenine and thymine homopolymer strings of at least 8 nucleotides (AT 8+mers) were characterized in subspecies I. The motif differed between other taxonomic classes but not between serovars. The motif in plasmids was possibly associated with serovar. Approximately 12.3% of the motif loci had mutations. Mutability of AT 8+mers suggests that genomes undergo frequent repair to maintain optimal gene content, and that the motif facilitates self-recognition; in addition, serovar diversity is associated with plasmid content. A theory that genome regeneration accounts for both persistence of predominant serovars and serovar diversity provides a new framework for investigating root causes of foodborne illness.
在亚种I中对至少8个核苷酸的腺嘌呤和胸腺嘧啶同聚物串（AT 8聚体）进行了表征。该基序在其他分类类别之间有所不同，但在血清型之间没有差异。质粒中的基序可能与血清型有关。大约12.3%的基序位点发生了突变。AT 8聚体的可变性表明基因组经常进行修复以维持最佳基因含量，并且该基序有助于自我识别；此外，血清型多样性与质粒含量相关。一种认为基因组再生既导致主要血清型的持续存在又导致血清型多样性的理论为调查食源性疾病的根本原因提供了一个新框架。
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