Department of Medicine III, Friedrich-Alexander University of Erlangen-Nürnberg, University Hospital Erlangen, Ulmenweg 18, 91054, Erlangen, Germany.
Institute of Medical Physics (IMP), Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Henkestr. 91, 91052, Erlangen, Germany.
Aging Clin Exp Res. 2022 Sep;34(9):2089-2098. doi: 10.1007/s40520-022-02149-1. Epub 2022 May 28.
Myosteatosis, skeletal muscle fat infiltration, is associated with inflammation and fibrosis. The age-related increase of myosteatosis is an important characteristic of sarcopenia and contributes to fragility.
To investigate the impact of healthy aging on intermuscular adipose tissue (IMAT) and muscle fat fraction (FF) in the thigh and the paraspinal muscles in males.
In 54 healthy males (age 20-70), all active hobby golfers, magnetic resonance imaging was performed to determine volume of IMAT, volume of muscle tissue (MT) and of percentage of FF.
Between ages 20-70, at the thigh, IMAT/MT volume and MT FF increased annually by 2.9% and 1.3%, respectively. At the psoas IMAT/Psoas volume did not change with age. MT FF increased by 1.5% annually. At the erector spinae IMAT/Erector volume decreased by 0.3% and MT FF increased by 2.8% annually.
With increasing age, in males, thigh muscle atrophied, muscle tissue was partly replaced by adipose tissue and remaining muscle tissue also contained more fat. Similar effects were observed in the erector spinae. The psoas muscle did not atrophy, although MT FF also increased with age. Overall correlations with age were weak to moderate with higher correlations observed in the paraspinal muscles.
Age-related increases of muscle fat infiltration were observed in the thigh and in the spine. Muscle atrophy did not occur in the psoas. In cross-sectional studies, an adjustment of volumetric parameters by muscle volume is advisable when comparing age-dependent results.
肌内脂肪增多症，即骨骼肌脂肪浸润，与炎症和纤维化有关。随着年龄的增长，肌内脂肪增多是肌肉减少症的一个重要特征，也是导致脆弱的原因之一。
研究健康老龄化对男性大腿和脊柱旁肌肉中肌间脂肪组织（IMAT）和肌肉脂肪分数（FF）的影响。
在 54 名健康男性（年龄 20-70 岁）中，所有参与者均为活跃的业余高尔夫球手，进行磁共振成像以确定 IMAT、肌肉组织（MT）的体积和 FF 的百分比。
在 20-70 岁之间，大腿处的 IMAT/MT 体积和 MT FF 每年分别增加 2.9%和 1.3%。腰大肌处的 IMAT/腰大肌体积与年龄无关。MT FF 每年增加 1.5%。竖脊肌处的 IMAT/竖脊肌体积减少 0.3%，MT FF 每年增加 2.8%。
随着年龄的增长，男性大腿肌肉萎缩，肌肉组织部分被脂肪组织取代，剩余的肌肉组织也含有更多的脂肪。在竖脊肌中也观察到类似的效果。尽管腰大肌的 MT FF 也随年龄增长而增加，但它并没有萎缩。与年龄的总体相关性为弱到中度，在脊柱旁肌肉中相关性更高。
在大腿和脊柱中观察到与年龄相关的肌肉脂肪浸润增加。腰大肌没有发生萎缩。在横断面研究中，当比较年龄相关结果时，建议通过肌肉体积调整体积参数。
