Daneshzad Elnaz, Heshmati Javad, Basirat Vahid, Keshavarz Seyed-Ali, Qorbani Mostafa, Larijani Bagher, Bellissimo Nick, Azadbakht Leila
Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran.
Songhor Healthcare Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Front Nutr. 2022 May 12;9:775543. doi: 10.3389/fnut.2022.775543. eCollection 2022.
Some dietary patterns may improve diabetes complications through scavenging oxidants and anti-inflammatory properties. This study evaluated the effect of the Dietary Approaches to Stop Hypertension (DASH) diet on sleep status, mental health, and hormonal changes among Iranian women with type 2 diabetes.
This randomized controlled trial (RCT) included 66 diabetic women. Participants were randomly divided into the two different diet groups (the DASH diet and control diet; 33 patients in each group) for 3 months. The Pittsburgh Sleep Quality Index and the Depression, Anxiety, and Stress Scale-21 items were used to assess sleep and mental disorders, respectively. Fasting blood sugar, hemoglobin A1c (HbA1c), advanced glycation end products (AGEs), as well as several sex hormones were evaluated at the beginning and the end of the trial.
Anthropometric indices, HbA1c (control: 8.77 ± 0.82 vs. 8.04 ± 1.03; the DASH diet 8.70 ± 1.05 vs.7.41 ± 1.03), and follicle-stimulating hormone (FSH) (control: 72.16 ± 26.02 vs. 68.12 ± 27.63; the DASH diet: 72.99 ± 25.19 vs. 67.43 ± 27.63) significantly decreased over 12 weeks in both the groups ( < .0001). Testosterone, 2-h postprandial glucose (2hPPG), and AGEs significantly decreased over 12 weeks in the DASH diet group. Sleep, depression, and anxiety scores significantly decreased over 12 weeks in the DASH diet group. Night sleep duration significantly increased over 12 weeks in the DASH diet group ( < 0.0001).
A 12-week DASH diet significantly decreases testosterone, 2hPPG, AGEs level, as well as sleep, depression, and anxiety scores in women with type 2 diabetes. However, more RCTs are needed to confirm these findings.
一些饮食模式可能通过清除氧化剂和抗炎特性来改善糖尿病并发症。本研究评估了终止高血压饮食疗法（DASH饮食）对伊朗2型糖尿病女性睡眠状况、心理健康和激素变化的影响。
这项随机对照试验（RCT）纳入了66名糖尿病女性。参与者被随机分为两个不同的饮食组（DASH饮食组和对照组；每组33名患者），为期3个月。匹兹堡睡眠质量指数和抑郁、焦虑和压力量表-21项分别用于评估睡眠和精神障碍。在试验开始和结束时评估空腹血糖、糖化血红蛋白（HbA1c）、晚期糖基化终产物（AGEs）以及几种性激素。
两组的人体测量指标、HbA1c（对照组：8.77±0.82对8.04±1.03；DASH饮食组：8.70±1.05对7.41±1.03）和促卵泡生成素（FSH）（对照组：72.16±26.02对68.12±27.63；DASH饮食组：72.99±25.19对67.43±27.63）在12周内均显著下降（P<0.0001）。DASH饮食组的睾酮、餐后2小时血糖（2hPPG）和AGEs在12周内显著下降。DASH饮食组的睡眠、抑郁和焦虑评分在12周内显著下降。DASH饮食组的夜间睡眠时间在12周内显著增加（P<0.0001）。
为期12周的DASH饮食可显著降低2型糖尿病女性的睾酮、2hPPG、AGEs水平以及睡眠、抑郁和焦虑评分。然而，需要更多的随机对照试验来证实这些发现。
