免疫功能低下宿主中的 COVID-19，包括人类免疫缺陷病毒感染者。
COVID-19 in the Immunocompromised Host, Including People with Human Immunodeficiency Virus.
机构信息
Department of Medicine, Division of Infectious Disease, Stanford University School of Medicine, 300 Pasteur Drive, Lane L134, Stanford, CA 94305, USA.
Department of Medicine, Division of Infectious Disease, Stanford University School of Medicine, 300 Pasteur Drive, Lane L134, Stanford, CA 94305, USA.
出版信息
Infect Dis Clin North Am. 2022 Jun;36(2):397-421. doi: 10.1016/j.idc.2022.01.006. Epub 2022 Feb 1.
Abstract
This review describes the incidence, epidemiology, and risk factors for mortality of COVID-19 in immunocompromised patients, including persons with human immunodeficiency virus. It describes various preventive measures, including vaccines and their effectiveness and the role of monoclonal antibodies for pre-exposure prophylaxis. It also reviews the different treatment options for immunocompromised individuals, including antivirals, monoclonal antibodies, and immunomodulators. Lastly, it describes the impact of COVID-19 on transplantation and continuity care of this population.
摘要
这篇综述描述了免疫功能低下患者（包括人类免疫缺陷病毒感染者）中 COVID-19 的发病率、流行病学和死亡率的风险因素。它描述了各种预防措施，包括疫苗及其有效性以及单克隆抗体在暴露前预防中的作用。它还回顾了免疫功能低下个体的不同治疗选择，包括抗病毒药物、单克隆抗体和免疫调节剂。最后，它描述了 COVID-19 对该人群移植和连续性护理的影响。
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