Agarawal Kopal, Anant Kulkarni Yogesh, Wairkar Sarika
Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKMs NMIMS, V.L.Mehta Road, Vile Parle (W), Mumbai, Maharashtra, 400056, India.
Drug Deliv Transl Res. 2023 Jan;13(1):18-36. doi: 10.1007/s13346-022-01174-x. Epub 2022 May 30.
Diabetes is a chronic metabolic disease characterized by an excess of glucose in the blood. If the constant sugar level is not managed correctly in diabetic patients, it may lead to microvascular complications such as diabetic retinopathy, neuropathy, and nephropathy. There are several synthetic drugs for the management of diabetes; however, these drugs produce immense adverse effects in long-term use. Flavonoids are naturally occurring substances categorized in various classes. They are known for their diverse pharmacological actions, and one of them is prominent antihyperglycemic action and their activities in diabetic complications. In the last few decades, many research studies emphasized the potential of flavonoids in diabetes management. Nevertheless, most flavonoids are insoluble in water and cannot produce desired therapeutic action when administered in conventional dosage forms. To overcome this issue, flavonoids were formulated into different nanoformulations to enhance solubility, absorption, and therapeutic efficacy. This review article focuses on flavonoid nanoformulations and in vitro and in vivo studies reported to overcome diabetes mellitus and its complications.
糖尿病是一种慢性代谢疾病，其特征是血液中葡萄糖过多。如果糖尿病患者的血糖水平持续得不到正确控制，可能会导致微血管并发症，如糖尿病视网膜病变、神经病变和肾病。有几种用于治疗糖尿病的合成药物；然而，这些药物长期使用会产生巨大的副作用。黄酮类化合物是天然存在的物质，分为不同类别。它们以其多样的药理作用而闻名，其中之一是显著的降血糖作用及其在糖尿病并发症中的活性。在过去几十年中，许多研究强调了黄酮类化合物在糖尿病管理中的潜力。然而，大多数黄酮类化合物不溶于水，以传统剂型给药时无法产生预期的治疗作用。为了克服这个问题，黄酮类化合物被制成不同的纳米制剂，以提高溶解度、吸收和治疗效果。这篇综述文章重点关注黄酮类纳米制剂以及为克服糖尿病及其并发症而进行的体外和体内研究。
