Department of Pediatrics, Chonnam National University Hospital, Chonnam National University Medical School, Jebong-ro, Dong-gu, Gwangju, 61469, Republic of Korea.
Department of Radiology, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Republic of Korea.
BMC Pulm Med. 2022 May 30;22(1):212. doi: 10.1186/s12890-022-02005-y.
The prevalence of refractory Mycoplasma pneumoniae (MP) pneumonia has been increasing. However, few studies have investigated the impact of respiratory virus coinfection in patients with MP pneumonia, and their results have been inconclusive. This study aimed to investigate the impact of respiratory virus coinfection in children hospitalized with MP pneumonia.
This study enrolled 145 children hospitalized with MP pneumonia between May 2019 and March 2020. The patients were divided into two groups: the respiratory virus coinfection and non-coinfection groups. All the children underwent polymerase chain reaction testing for respiratory virus infection. Information on clinical, laboratory, and radiologic findings were obtained retrospectively via medical chart reviews.
Children in the respiratory virus coinfection group were younger than those in the non-coinfection group. Respiratory virus coinfection in children hospitalized with MP pneumonia was significantly associated with persistence of fever more than 6 days (adjusted odds ratio [aOR], 2.394; 95% confidence interval [95% CI], 1.172-4.892), severe pneumonia (aOR, 4.602; 95% CI, 1.154-18.353), and poor response to the stepwise approach for MP pneumonia (aOR, 4.354; 95% CI, 1.374-13.800). In addition, higher levels of liver enzymes and lactate dehydrogenase at admission were associated with respiratory virus coinfection in children with MP pneumonia.
The results of this study suggest that respiratory virus coinfection in children hospitalized with MP pneumonia may be associated with refractory MP pneumonia.
难治性肺炎支原体（MP）肺炎的患病率一直在上升。然而，很少有研究调查呼吸道病毒合并感染对 MP 肺炎患者的影响，且其结果尚无定论。本研究旨在探讨呼吸道病毒合并感染对住院的 MP 肺炎患儿的影响。
本研究纳入了 2019 年 5 月至 2020 年 3 月期间因 MP 肺炎住院的 145 名儿童。将患者分为呼吸道病毒合并感染组和非合并感染组。所有患儿均接受呼吸道病毒感染聚合酶链反应检测。通过病历回顾，获取临床、实验室和影像学检查的相关信息。
呼吸道病毒合并感染组患儿的年龄小于非合并感染组。儿童住院的 MP 肺炎合并呼吸道病毒感染与发热持续 6 天以上（调整优势比[aOR]，2.394；95%置信区间[95%CI]，1.172-4.892）、重症肺炎（aOR，4.602；95%CI，1.154-18.353）和 MP 肺炎阶梯式治疗方案反应不佳（aOR，4.354；95%CI，1.374-13.800）显著相关。此外，入院时肝酶和乳酸脱氢酶水平较高与 MP 肺炎患儿合并呼吸道病毒感染相关。
本研究结果提示，住院的 MP 肺炎患儿合并呼吸道病毒感染可能与难治性 MP 肺炎相关。
