1例弹性假黄瘤患者单侧急性视网膜病变发作后出现脉络膜新生血管的血管样条纹病例。
A case of angioid streaks that produced choroidal neovascularization after the onset of unilateral acute retinopathy in pseudoxanthoma elasticum.
作者信息
Kyo Akika, Yamamoto Manabu, Honda Shigeru
机构信息
Department of Ophthalmology and Visual Sciences, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
出版信息
Am J Ophthalmol Case Rep. 2022 May 19;27:101591. doi: 10.1016/j.ajoc.2022.101591. eCollection 2022 Sep.
PURPOSE
To report a case of angioid streaks that showed non-exudative choroidal neovascularization (CNV) after the onset of acute retinopathy in pseudoxanthoma elasticum (PXE).
OBSERVATIONS
A 64-year-old woman with PXE visited our department for an ophthalmologic evaluation. Her decimal best-corrected visual acuity (BCVA) was 1.5, with angioid streaks (AS) around the optic disc in either eye at the first visit. Seven years later, her left eye's BCVA suddenly decreased by 0.3, and the fundus showed blurring of the Ellipsoid zone and vitreous cells along with the retinal pigment streaks on the nasal fovea. Diagnosed as acute retinopathy in PXE, twenty-two weeks after the start of oral prednisolone, the Ellipsoid zone became clear and the BCVA improved to 1.2, but CNV gradually developed. After intravitreal injection of bevacizumab, the CNV was decreased.
CONCLUSIONS AND IMPORTANCE
CNV on the AS lesion may occur after acute retinopathy in PXE.
目的
报告1例弹性假黄瘤（PXE）急性视网膜病变发作后出现非渗出性脉络膜新生血管（CNV）的血管样条纹病例。
观察结果
一名患有PXE的64岁女性因眼科评估前来我科就诊。初次就诊时，她的小数最佳矫正视力（BCVA）为1.5，双眼视盘周围均有血管样条纹（AS）。7年后，她左眼的BCVA突然下降了0.3，眼底显示椭圆体带模糊、玻璃体细胞以及鼻侧黄斑区的视网膜色素条纹。诊断为PXE急性视网膜病变，口服泼尼松龙22周后，椭圆体带变清晰，BCVA提高到1.2，但CNV逐渐发展。玻璃体内注射贝伐单抗后，CNV减少。
结论与意义
PXE急性视网膜病变后，AS病变处可能会发生CNV。
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