Spagnuolo Rocco, Iaquinta Francesco Salvatore, Mauro Daniele, Pantano Ilenia, Dastoli Stefano, Naty Saverio, Cosco Cristina, Mancina Rosellina Margherita, Iacono Daniela, Gaggiano Emanuela, Ruggiero Annarita, Nisticò Steven Paul, Ciccia Francesco, Grembiale Rosa Daniela, Patrizia Doldo
Department of Clinical and Experimental Medicine, Magna Graecia University of Catanzaro, Calabria, Catanzaro, Italy.
Department of Health Sciences Magna Graecia University of Catanzaro, Calabria, Catanzaro, Italy.
Rev Recent Clin Trials. 2022 May 31. doi: 10.2174/1574887117666220531162104.
Although mood disorders have been well characterized in Immune-mediated inflammatory diseases, physical function and satisfaction in social roles have not yet been defined as independent domains.
The study aims to assess satisfaction in social roles and physical function alterations in an Immune-mediated inflammatory diseases population and identify associated characteristics.
Physical function and social roles satisfaction were evaluated through the Patient-Reported Outcomes Measurement System. Besides comparisons between groups, univariate and multivariable logistic regression were performed to identify independent predictors.
Two hundred sixty-five Immune-mediated Inflammatory Diseases patients and 206 controls were recruited. Compared with controls, Inflammatory Bowel Diseases patients had impaired physical function (p<0.001), while Inflammatory Arthritis patients reported impairment in both domains (p<0.001, each). In the univariate logistic regression, gender, high school educational level, physical activity and occupation were positively associated with physical function and social role satisfaction (p<0.001; p=0.001; p<0.001; p=0.001 and p<0.001; p=0.012; p=0.008; p=0.004, respectively). Active disease and steroids were inversely associated with physical function and social roles satisfaction (p=0.033; p=0.022 and p=0.002; p=0.038, respectively). Further associations were found between age and physical function (p=0.002); biological treatment and ESR with social roles satisfaction (p<0.001; p=0.043; respectively). In the multivariable regression, gender remained associated with physical function (p<0.001) and social roles satisfaction (p=0.003). Negatively associated factors were biological treatment for satisfaction in social roles (p<0.001) and steroids for physical function (p=0.021) and social roles satisfaction (p=0.018).
Immune-mediated Inflammatory diseases determine alterations in physical function and social life satisfaction. Gender and treatment are independent associated factors. Patient-Reported Outcomes should be considered in clinical management to define patients' real needs.
尽管情绪障碍在免疫介导的炎症性疾病中已有充分描述，但身体功能和社会角色满意度尚未被定义为独立的领域。
本研究旨在评估免疫介导的炎症性疾病人群的社会角色满意度和身体功能改变，并确定相关特征。
通过患者报告结局测量系统评估身体功能和社会角色满意度。除了组间比较外，还进行了单变量和多变量逻辑回归以确定独立预测因素。
招募了265名免疫介导的炎症性疾病患者和206名对照。与对照组相比，炎症性肠病患者的身体功能受损（p<0.001），而炎症性关节炎患者在两个领域均有受损（p<0.001，各领域）。在单变量逻辑回归中，性别、高中学历、身体活动和职业与身体功能和社会角色满意度呈正相关（分别为p<0.001；p=0.001；p<0.001；p=0.001和p<0.001；p=0.012；p=0.008；p=0.004）。疾病活动和使用类固醇与身体功能和社会角色满意度呈负相关（分别为p=0.033；p=0.022和p=0.002；p=0.038）。还发现年龄与身体功能之间存在进一步关联（p=0.002）；生物治疗和血沉与社会角色满意度之间存在关联（分别为p<0.001；p=0.043）。在多变量回归中，性别仍与身体功能（p<0.001）和社会角色满意度（p=0.003）相关。负相关因素包括生物治疗对社会角色满意度的影响（p<0.001），类固醇对身体功能的影响（p=0.021）以及对社会角色满意度的影响（p=0.018）。
免疫介导的炎症性疾病会导致身体功能和社会生活满意度的改变。性别和治疗是独立的相关因素。在临床管理中应考虑患者报告结局，以明确患者的实际需求。
