Almutairi Nawaf, Shaaban Dalia
Department of Medicine, Faculty of Medicine, Kuwait University, Kuwait.
Department of Dermatology, Farwaniya Hospital, Farwaniya, Kuwait.
Postepy Dermatol Alergol. 2022 Apr;39(2):368-374. doi: 10.5114/ada.2021.107098. Epub 2021 Jun 20.
Psoriasis is a chronic immune-mediated inflammatory disease. Environmental factors including diet have been supposed to play a role in its pathogenesis. Fasting in Ramadan consists of intermittent fasting in which participating Muslims refrain from eating and drinking from dawn up to sunset.
To validate the possible clinical consequences of Ramadan fasting for patients with psoriasis.
The study was conducted in Ramadan 2019. It included patients over 18 years who were diagnosed with stable chronic plaque psoriasis. PASI and BSA scores, body mass index and biochemical tests (including blood lipids, fasting blood glucose) were compared before and after a month of Ramadan fasting.
The study included 121 psoriasis patients. The mean PASI score was 4.36 ±3.22 at the beginning of the study, which was reduced to 3.51 ±1.26 at the end of the study. The difference was statistically significant ( 0.001). There was no difference in the change of weight. We found a statistically significant difference in fasting plasma glucose, HDL and triglycerides. Only mild adverse events were noted during the study period.
Ramadan intermittent fasting has beneficial effects on severity of the disease in psoriasis patients with a reduction in PASI score and no serious health hazards. Thus, Ramadan intermittent fasting could be considered during treatment of psoriasis patients.
银屑病是一种慢性免疫介导的炎症性疾病。包括饮食在内的环境因素被认为在其发病机制中起作用。斋月禁食包括间歇性禁食，参与的穆斯林从黎明到日落期间禁食禁饮。
验证斋月禁食对银屑病患者可能产生的临床后果。
该研究于2019年斋月期间进行。纳入了18岁以上被诊断为稳定期慢性斑块状银屑病的患者。比较了斋月禁食一个月前后的银屑病面积和严重程度指数（PASI）、体表面积（BSA）评分、体重指数以及生化检查（包括血脂、空腹血糖）。
该研究纳入了121例银屑病患者。研究开始时平均PASI评分为4.36±3.22，研究结束时降至3.51±1.26。差异具有统计学意义（P<0.001）。体重变化无差异。我们发现空腹血糖、高密度脂蛋白（HDL）和甘油三酯有统计学意义的差异。研究期间仅记录到轻度不良事件。
斋月间歇性禁食对银屑病患者的病情严重程度有有益影响，PASI评分降低且无严重健康危害。因此，在银屑病患者的治疗过程中可考虑斋月间歇性禁食。
