Wang Jingyu, Song Weiye, Sadlak Natalie, Fiorello Marissa G, Desai Manishi, Yi Ji
Department of Ophthalmology, School of Medicine, Johns Hopkins University, Baltimore, MD, United States.
School of Mechanical Engineering, Shandong University, Jinan, China.
Front Med (Lausanne). 2022 May 12;9:886576. doi: 10.3389/fmed.2022.886576. eCollection 2022.
The retinal macula is at the center of our visual field, and thus pathological damage in the macula significantly impacts an individual's quality of life. The parafoveal vessels form the inner retina provide oxygen perfusion, and the measurement of parafoveal oxygen saturation (sO) can evaluate macular metabolism and provide pathophysiological insight. In this paper, for the first time, we present a baseline study of microvascular oxygen saturation (sO) in perifoveal macular region using visible light optical coherence tomography (VIS-OCT) on normal eyes. The arterial and venous sO from all eyes was 92.1 ± 7.1 (vol %) and 48.4 ± 5.0 (vol %) (mean ± SD), respectively. Arteriovenous sO difference was 43.8 ± 9.5 (vol %). Marginal correlation was found between venous sO and intraocular pressure (IOP) among eyes. No significant correlation was found between sO and vessel topological features, including length, diameter, and distance to fovea. This baseline study could serve as a benchmark for the future sO investigation of retinal macular pathologies.
视网膜黄斑位于我们视野的中心，因此黄斑的病理性损伤会显著影响个人的生活质量。黄斑旁血管为视网膜内层提供氧气灌注，测量黄斑旁血氧饱和度（sO）可以评估黄斑代谢并提供病理生理学方面的见解。在本文中，我们首次使用可见光光学相干断层扫描（VIS-OCT）对正常眼睛的黄斑旁区域微血管血氧饱和度（sO）进行了基线研究。所有眼睛的动脉和静脉sO分别为92.1±7.1（体积%）和48.4±5.0（体积%）（平均值±标准差）。动静脉sO差值为43.8±9.5（体积%）。在各眼中，发现静脉sO与眼压（IOP）之间存在边缘相关性。未发现sO与血管拓扑特征（包括长度、直径和到中央凹的距离）之间存在显著相关性。这项基线研究可为未来视网膜黄斑病变的sO研究提供基准。
