Laegreid A, Kolstø Otnaess A B, Orstavik I, Carlsen K H
Acta Paediatr Scand. 1986 Sep;75(5):696-701. doi: 10.1111/j.1651-2227.1986.tb10276.x.
Neutralizing activity against respiratory syncytial virus (RSV) was measured in milk samples from 17 healthy women whose infants had an acute infection with respiratory syncytial virus (RSV) and from 27 women with healthy infants. All milk samples were obtained 2-8 months post partum. Neutralizing activity was detected in 36 samples. No major difference in neutralizing titers was observed between the two groups, and the titers were low. RSV-specific IgA was found in two samples, and RSV-specific IgG in one sample. RSV-specific IgM was not detected. In gel filtration studies, the neutralizing activity was eluted with an apparent molecular weight above 400,000. The neutralizing activity remained after removal of IgA by affinity chromatography. These findings suggest that both immunoglobulin and non-immunoglobulin components in human milk can neutralize RSV.
在17名婴儿患有呼吸道合胞病毒（RSV）急性感染的健康女性以及27名婴儿健康的女性的乳汁样本中，检测了针对呼吸道合胞病毒（RSV）的中和活性。所有乳汁样本均在产后2至8个月采集。在36份样本中检测到了中和活性。两组之间的中和滴度未观察到显著差异，且滴度较低。在两份样本中发现了RSV特异性IgA，在一份样本中发现了RSV特异性IgG。未检测到RSV特异性IgM。在凝胶过滤研究中，中和活性以表观分子量高于400,000被洗脱。通过亲和层析去除IgA后，中和活性仍然存在。这些发现表明，人乳中的免疫球蛋白和非免疫球蛋白成分均可中和RSV。
