National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Center for International Research on Tropical Diseases, Shanghai, China; School of Global Health, Chinese Center for Tropical Diseases Research-Shanghai Jiao Tong University School of Medicine, Shanghai, China.
National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Center for International Research on Tropical Diseases, Shanghai, China.
Acta Trop. 2022 Sep;233:106545. doi: 10.1016/j.actatropica.2022.106545. Epub 2022 May 29.
Clonorchiasis is caused by the ingestion of raw freshwater fish and causes high burden in East Asia. The epidemiological profiles and determinants of C. sinensis infection, knowledge, practice and attitude related to clonorchiasis were demonstrated in Hengxian county, Guangxi, China. The overall prevalence of C. sinensis was 60.3%, which was higher in male than in female and in elder population compared to children. The percentage knowing local transmission, transmission route and harm of C. sinensis was 20.9%, 31.4% and 32.5%. A percentage of 60.4% reported ingestion of raw freshwater fish, while 70.1% persons would like to accept treatment if infected with C. sinensis. Of the individuals ingesting raw freshwater fish, 82.0% did at home and 81.3% drunk alcohol when ingesting raw freshwater fish. Sixty-two percent showed the persistence on ingestion of raw freshwater fish in future. The ingestion of raw freshwater fish varied by seasons, with a proportion of 57.8% in spring, 48.3% in summer, 60.2% in autumn and 92.2% in winter. In multivariable regression models, age groups, history with C. sinensis treatment, and frequency on ingesting raw freshwater fish were related to C. sinensis infection, while gender, educational level, history with C. sinensis infection, and knowing local transmission were related to the practice of ingesting raw freshwater fish. Gender, history with C. sinensis treatment, frequency on ingesting raw freshwater fish, duration of ingesting raw freshwater fish and drinking alcohol when ingesting raw freshwater fish were associated to the attitude to the ingestion of raw freshwater fish in future. Great efforts are needed to combat clonorchiasis, in which the heterogeneity of population in knowledge, practice, attitude and infection needs to be considered. Men are of crucial importance in term of the morbidity control through chemotherapy. Meanwhile, massive education is expected to implement, which needs to promote the change of ingesting raw freshwater fish for sustainable control of clonorchiasis.
华支睾吸虫病是由生食淡水鱼引起的，在东亚地区负担沉重。本研究对华安县的肝吸虫病流行特征和决定因素、相关知识、实践和态度进行了分析。华支睾吸虫总感染率为 60.3%，男性高于女性，老年人高于儿童。对当地传播、传播途径和肝吸虫危害的知晓率分别为 20.9%、31.4%和 32.5%。60.4%的人报告曾食用生淡水鱼，70.1%的人如果感染肝吸虫愿意接受治疗。在食用生淡水鱼的人群中，82.0%在家中食用，81.3%在食用生淡水鱼时饮酒。62%的人表示将来会继续食用生淡水鱼。食用生淡水鱼的季节性差异较大，春季占 57.8%，夏季占 48.3%，秋季占 60.2%，冬季占 92.2%。多变量回归模型显示，年龄组、肝吸虫治疗史和生食淡水鱼频率与肝吸虫感染有关，而性别、教育程度、肝吸虫感染史和知晓当地传播与生食淡水鱼的实践有关。性别、肝吸虫治疗史、生食淡水鱼频率、生食淡水鱼持续时间和生食淡水鱼时饮酒与未来对生食淡水鱼的态度有关。需要大力开展肝吸虫病防治工作，在防治工作中要考虑到人群在知识、实践、态度和感染方面的异质性。通过化疗控制发病率，男性至关重要。同时，需要开展大规模教育，促进生食淡水鱼习惯的改变，以实现可持续控制肝吸虫病。
