Arisaka M, Arisaka O, Nittono H, Obinata K, Niijima S, Yabuta K, Suzuki F, Yanagawa S
Acta Paediatr Scand. 1986 Sep;75(5):875-8. doi: 10.1111/j.1651-2227.1986.tb10309.x.
A 5-month-old boy with giant cell hepatitis died of hepatic failure. Analysis of serum bile acids by high pressure liquid chromatography revealed a marked increase in total bile acid concentration and a decrease in the cholate to chenodeoxycholate ratio. However, contrary to expectation, the conjugating ability of bile acids with taurine or glycine was well preserved. This suggests that the amino acid conjugation can occur despite the presence of severe hepatocellular damage.
一名患有巨细胞性肝炎的5个月大男婴死于肝衰竭。通过高压液相色谱法分析血清胆汁酸发现，总胆汁酸浓度显著升高，胆酸盐与鹅去氧胆酸盐的比例降低。然而，与预期相反，胆汁酸与牛磺酸或甘氨酸的结合能力保存良好。这表明，尽管存在严重的肝细胞损伤，氨基酸结合仍可发生。
