肝病中的血清胆汁酸
Serum bile acids in liver disease.
作者信息
Neale G, Lewis B, Weaver V, Panveliwalla D
出版信息
Gut. 1971 Feb;12(2):145-52. doi: 10.1136/gut.12.2.145.
Abstract
Serum bile acids have been measured in patients with a wide variety of liver diseases using a technique which separates the major individual conjugated and free bile acids. Total serum bile acids may be elevated up to 100 times the normal concentration in patients with liver disease and this increase consists largely of conjugated bile acids. The ratio of glycine-conjugated to taurine-conjugated bile salts is low in all types of liver disease and this is found particularly in the serum of patients with obstructive jaundice. There is a decrease in the ratio of trihydroxy:dihydroxy cholanic acid in patients with cirrhosis.
摘要
使用一种可分离主要的单个结合型和游离型胆汁酸的技术，对患有多种肝脏疾病的患者进行了血清胆汁酸检测。在患有肝脏疾病的患者中，血清总胆汁酸可能升高至正常浓度的100倍，且这种升高主要由结合型胆汁酸组成。在所有类型的肝脏疾病中，甘氨酸结合型与牛磺酸结合型胆汁盐的比例都较低，这在梗阻性黄疸患者的血清中尤为明显。肝硬化患者中三羟基胆烷酸与二羟基胆烷酸的比例降低。
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