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Tau Beats Amyloid in Predicting Brain Atrophy in Alzheimer Disease: Implications for Prognosis and Clinical Trials.

作者信息

Malpetti Maura, Joie Renaud La, Rabinovici Gil D

机构信息

Memory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, California;

Department of Clinical Neurosciences, University of Cambridge, Cambridge, United Kingdom; and.

出版信息

J Nucl Med. 2022 Jun;63(6):830-832. doi: 10.2967/jnumed.121.263694.

DOI:10.2967/jnumed.121.263694
PMID:35649659
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9157718/
Abstract
摘要

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JAMA Neurol. 2022 Feb 1;79(2):149-158. doi: 10.1001/jamaneurol.2021.4654.
2
Plasma phosphorylated tau 217 and phosphorylated tau 181 as biomarkers in Alzheimer's disease and frontotemporal lobar degeneration: a retrospective diagnostic performance study.血浆磷酸化 tau 217 和磷酸化 tau 181 作为阿尔茨海默病和额颞叶变性的生物标志物：一项回顾性诊断性能研究。
Lancet Neurol. 2021 Sep;20(9):739-752. doi: 10.1016/S1474-4422(21)00214-3.
3
Accuracy of Tau Positron Emission Tomography as a Prognostic Marker in Preclinical and Prodromal Alzheimer Disease: A Head-to-Head Comparison Against Amyloid Positron Emission Tomography and Magnetic Resonance Imaging.Tau 正电子发射断层扫描作为临床前和前驱期阿尔茨海默病预后标志物的准确性：与淀粉样蛋白正电子发射断层扫描和磁共振成像的头对头比较。
JAMA Neurol. 2021 Aug 1;78(8):961-971. doi: 10.1001/jamaneurol.2021.1858.
4
Four distinct trajectories of tau deposition identified in Alzheimer's disease.阿尔茨海默病中tau 沉积的四种不同轨迹。
Nat Med. 2021 May;27(5):871-881. doi: 10.1038/s41591-021-01309-6. Epub 2021 Apr 29.
5
Donanemab in Early Alzheimer's Disease.多奈单抗用于早期阿尔茨海默病
N Engl J Med. 2021 May 6;384(18):1691-1704. doi: 10.1056/NEJMoa2100708. Epub 2021 Mar 13.
6
Comorbid neuropathological diagnoses in early versus late-onset Alzheimer's disease.早发性与晚发性阿尔茨海默病的共病神经病理学诊断。
Brain. 2021 Aug 17;144(7):2186-2198. doi: 10.1093/brain/awab099.
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Plasma p-tau231: a new biomarker for incipient Alzheimer's disease pathology.血浆 p-tau231：早期阿尔茨海默病病理学的新生物标志物。
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