长时间纯母乳喂养会导致血清中免疫球蛋白G、A和M的浓度降低。

Prolonged exclusive breast-feeding results in low serum concentrations of immunoglobulin G, A and M.

作者信息

Savilahti E, Salmenperä L, Tainio V M, Halme H, Perheentupa J, Siimes M A

出版信息

Acta Paediatr Scand. 1987 Jan;76(1):1-6. doi: 10.1111/j.1651-2227.1987.tb10404.x.

DOI:10.1111/j.1651-2227.1987.tb10404.x

Abstract

Serum levels of IgG, IgA and IgM were measured in 198 infants at ages 2, 4, 6, 9 and 12 months. By age 9 months 30 infants were still exclusively breast-fed; their IgG and IgM levels were significantly lower than those of infants weaned early to formula (before age 3.5 months). By 12 months 6 infants were still exclusively breast-fed; their IgA levels were by then also similarly lower. There was no significant difference in the number of infections experienced by these groups of infants. After 2 months on formula feeding, the IgG and IgM levels of the infants who were exclusively breast-fed for 9 months had caught up with the levels of the infants weaned early to formula. Only at 12 months of age prealbumin levels of the exclusively breast-fed infants showed a positive correlation to IgG and IgA levels; no correlation was found between immunoglobulin levels and levels of serum iron and zinc.

摘要

对198名2个月、4个月、6个月、9个月和12个月大的婴儿进行了血清IgG、IgA和IgM水平的测量。到9个月大时，有30名婴儿仍完全母乳喂养；他们的IgG和IgM水平显著低于过早断奶改用配方奶喂养的婴儿（3.5个月之前断奶）。到12个月大时，有6名婴儿仍完全母乳喂养；那时他们的IgA水平也同样较低。这些组别的婴儿经历感染的次数没有显著差异。在改用配方奶喂养2个月后，9个月纯母乳喂养婴儿的IgG和IgM水平赶上了过早断奶改用配方奶喂养婴儿的水平。仅在12个月大时，纯母乳喂养婴儿的前白蛋白水平与IgG和IgA水平呈正相关；未发现免疫球蛋白水平与血清铁和锌水平之间存在相关性。