在太空飞行和后肢卸载导致负重减少后，α-klotho水平会降低。

Willey Jeffrey S, Aunon-Chancellor Serena, Miles Lauren A, Moore Joseph E, Mao Xiao W, Wallace Robert W, Foy Matthew C

Department of Radiation Oncology, Wake Forest School of Medicine, Section of Radiation Biology, Winston-Salem, NC, USA.

Department of Internal Medicine, Louisiana State University Medical Center, Baton Rouge, LA, USA.

NPJ Microgravity. 2022 Jun 2;8(1):18. doi: 10.1038/s41526-022-00203-w.

Alpha(α)Klotho, a soluble transmembrane protein, facilitates calcium-phosphorus homeostasis through feedback between bone and kidney and is a potential systemic biomarker for bone-kidney health during spaceflight. We determined if: (1) plasma αKlotho was reduced after both spaceflight aboard the ISS and hindlimb unloading (HU); and (2) deficiency could be reversed with exercise. Both spaceflight and HU lowered circulating plasma αKlotho: plasma αKlotho recovered with exercise after HU.

α（阿尔法）-klotho是一种可溶性跨膜蛋白，通过骨骼与肾脏之间的反馈调节促进钙磷稳态，是太空飞行期间骨骼-肾脏健康的潜在系统性生物标志物。我们研究了：（1）国际空间站（ISS）飞行和后肢卸载（HU）后血浆α-klotho是否降低；（2）缺乏状态能否通过运动逆转。太空飞行和HU均降低了循环血浆α-klotho水平：HU后运动可使血浆α-klotho恢复。