• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

在太空飞行和后肢卸载导致负重减少后，α-klotho水平会降低。

αKlotho decreases after reduced weight-bearing from both spaceflight and hindlimb unloading.

作者信息

Willey Jeffrey S, Aunon-Chancellor Serena, Miles Lauren A, Moore Joseph E, Mao Xiao W, Wallace Robert W, Foy Matthew C

机构信息

Department of Radiation Oncology, Wake Forest School of Medicine, Section of Radiation Biology, Winston-Salem, NC, USA.

Department of Internal Medicine, Louisiana State University Medical Center, Baton Rouge, LA, USA.

出版信息

NPJ Microgravity. 2022 Jun 2;8(1):18. doi: 10.1038/s41526-022-00203-w.

DOI:10.1038/s41526-022-00203-w
PMID:35654945
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9163032/
Abstract

Alpha(α)Klotho, a soluble transmembrane protein, facilitates calcium-phosphorus homeostasis through feedback between bone and kidney and is a potential systemic biomarker for bone-kidney health during spaceflight. We determined if: (1) plasma αKlotho was reduced after both spaceflight aboard the ISS and hindlimb unloading (HU); and (2) deficiency could be reversed with exercise. Both spaceflight and HU lowered circulating plasma αKlotho: plasma αKlotho recovered with exercise after HU.

摘要

α（阿尔法）-klotho是一种可溶性跨膜蛋白，通过骨骼与肾脏之间的反馈调节促进钙磷稳态，是太空飞行期间骨骼-肾脏健康的潜在系统性生物标志物。我们研究了：（1）国际空间站（ISS）飞行和后肢卸载（HU）后血浆α-klotho是否降低；（2）缺乏状态能否通过运动逆转。太空飞行和HU均降低了循环血浆α-klotho水平：HU后运动可使血浆α-klotho恢复。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/111d/9163032/8ac68ebe3dfe/41526_2022_203_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/111d/9163032/7dfaa4da7a47/41526_2022_203_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/111d/9163032/91fc9bad6f5a/41526_2022_203_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/111d/9163032/8ac68ebe3dfe/41526_2022_203_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/111d/9163032/7dfaa4da7a47/41526_2022_203_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/111d/9163032/91fc9bad6f5a/41526_2022_203_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/111d/9163032/8ac68ebe3dfe/41526_2022_203_Fig3_HTML.jpg

相似文献

1
αKlotho decreases after reduced weight-bearing from both spaceflight and hindlimb unloading.在太空飞行和后肢卸载导致负重减少后，α-klotho水平会降低。
NPJ Microgravity. 2022 Jun 2;8(1):18. doi: 10.1038/s41526-022-00203-w.
2
Hindlimb unloading: rodent analog for microgravity.后肢去负荷：模拟微重力的啮齿动物模型
J Appl Physiol (1985). 2016 May 15;120(10):1196-206. doi: 10.1152/japplphysiol.00997.2015. Epub 2016 Feb 11.
3
Spaceflight and hind limb unloading induces an arthritic phenotype in knee articular cartilage and menisci of rodents.航天飞行和后肢去负荷会在啮齿类动物的膝关节软骨和半月板中引起关节炎表型。
Sci Rep. 2021 May 18;11(1):10469. doi: 10.1038/s41598-021-90010-2.
4
Forces associated with launch into space do not impact bone fracture healing.进入太空的力不会影响骨折愈合。
Life Sci Space Res (Amst). 2018 Feb;16:52-62. doi: 10.1016/j.lssr.2017.11.002. Epub 2017 Nov 11.
5
Role of αKlotho and FGF23 in regulation of type II Na-dependent phosphate co-transporters.αKlotho 和 FGF23 在 II 型 Na 依赖性磷酸盐共转运蛋白调节中的作用。
Pflugers Arch. 2019 Jan;471(1):99-108. doi: 10.1007/s00424-018-2238-5. Epub 2018 Dec 1.
6
Acute lung injury complicating acute kidney injury: A model of endogenous αKlotho deficiency and distant organ dysfunction.急性肾损伤并发急性肺损伤：内源性α-klotho缺乏与远隔器官功能障碍模型
Bone. 2017 Jul;100:100-109. doi: 10.1016/j.bone.2017.03.047. Epub 2017 Mar 24.
7
The effect of long-term hindlimb unloading on the expression of risk neurogenes encoding elements of serotonin-, dopaminergic systems and apoptosis; comparison with the effect of actual spaceflight on mouse brain.长期后肢卸载对编码5-羟色胺能、多巴胺能系统元件及凋亡的风险神经基因表达的影响；与实际太空飞行对小鼠大脑的影响的比较。
Neurosci Lett. 2017 Feb 15;640:88-92. doi: 10.1016/j.neulet.2017.01.023. Epub 2017 Jan 12.
8
Moderate intensity resistive exercise improves metaphyseal cancellous bone recovery following an initial disuse period, but does not mitigate decrements during a subsequent disuse period in adult rats.中等强度抗阻运动可改善成年大鼠在初始废用期后的干骺端松质骨恢复，但不能减轻随后废用期的骨量减少。
Bone. 2014 Sep;66:296-305. doi: 10.1016/j.bone.2014.06.005. Epub 2014 Jun 11.
9
Long-term hindlimb unloading causes a preferential reduction of medullary thymic epithelial cells expressing autoimmune regulator (Aire).长期后肢去负荷导致表达自身免疫调节因子（Aire）的骨髓胸腺上皮细胞优先减少。
Biochem Biophys Res Commun. 2018 Jun 27;501(3):745-750. doi: 10.1016/j.bbrc.2018.05.060.
10
Whole-body vibration and resistance exercise prevent long-term hindlimb unloading-induced bone loss: independent and interactive effects.全身振动和抗阻运动预防长期下肢废用性骨丢失：独立和交互作用。
Eur J Appl Physiol. 2012 Nov;112(11):3743-53. doi: 10.1007/s00421-012-2355-3. Epub 2012 Feb 28.

引用本文的文献

1
Exercise attenuates bed rest-induced increases in insulin resistance while α-klotho increases in 55 to 65 year-old women and men.运动可减轻卧床休息引起的胰岛素抵抗增加，而在55至65岁的女性和男性中，α-klotho会增加。
Sci Rep. 2025 Jul 24;15(1):26927. doi: 10.1038/s41598-025-12770-5.

本文引用的文献

1
Acute Impacts of Different Types of Exercise on Circulating α-Klotho Protein Levels.不同类型运动对循环中α-klotho蛋白水平的急性影响。
Front Physiol. 2021 Sep 1;12:716473. doi: 10.3389/fphys.2021.716473. eCollection 2021.
2
Spaceflight and hind limb unloading induces an arthritic phenotype in knee articular cartilage and menisci of rodents.航天飞行和后肢去负荷会在啮齿类动物的膝关节软骨和半月板中引起关节炎表型。
Sci Rep. 2021 May 18;11(1):10469. doi: 10.1038/s41598-021-90010-2.
3
Comprehensive Multi-omics Analysis Reveals Mitochondrial Stress as a Central Biological Hub for Spaceflight Impact.
综合多组学分析揭示了线粒体应激作为航天影响的中心生物学枢纽。
Cell. 2020 Nov 25;183(5):1185-1201.e20. doi: 10.1016/j.cell.2020.11.002.
4
Dietary countermeasure mitigates simulated spaceflight-induced osteopenia in mice.饮食对策可缓解模拟太空飞行引起的小鼠骨质疏松症。
Sci Rep. 2020 Apr 16;10(1):6484. doi: 10.1038/s41598-020-63404-x.
5
A human mission to Mars: Predicting the bone mineral density loss of astronauts.人类登陆火星任务：预测宇航员的骨密度损失。
PLoS One. 2020 Jan 22;15(1):e0226434. doi: 10.1371/journal.pone.0226434. eCollection 2020.
6
Resistive exercise in astronauts on prolonged spaceflights provides partial protection against spaceflight-induced bone loss.抗阻运动对长期航天飞行中的宇航员提供了部分保护，防止航天飞行引起的骨质流失。
Bone. 2019 Nov;128:112037. doi: 10.1016/j.bone.2019.07.013. Epub 2019 Aug 7.
7
Exercise training increases the S-Klotho plasma levels in sedentary middle-aged adults: A randomised controlled trial. The FIT-AGEING study.运动训练可增加久坐中年成年人的 S-Klotho 血浆水平：一项随机对照试验。FIT-AGEING 研究。
J Sports Sci. 2019 Oct;37(19):2175-2183. doi: 10.1080/02640414.2019.1626048. Epub 2019 Jun 4.
8
The Klotho proteins in health and disease.Klotho 蛋白与健康和疾病。
Nat Rev Nephrol. 2019 Jan;15(1):27-44. doi: 10.1038/s41581-018-0078-3.
9
Skeletal changes during and after spaceflight.航天飞行期间和之后的骨骼变化。
Nat Rev Rheumatol. 2018 Mar 21;14(4):229-245. doi: 10.1038/nrrheum.2018.37.
10
Phosphate and Klotho.磷酸盐和 Klotho。
Kidney Int. 2011 Apr;79121:S20-3. doi: 10.1038/ki.2011.26.