Harsha Makam S, Bhatia Pradeep K, Sharma Ankur, Sethi Priyanka
Department of Anesthesia and Critical Care, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
Department of Trauma and Emergency (Anesthesia), All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
Indian J Crit Care Med. 2022 Summer;26(4):491-495. doi: 10.5005/jp-journals-10071-24183.
The quantium consciousness index (qCON), an electroencephalography (EEG)-based modality, has no studies regarding intensive care unit (ICU) sedation, though very few studies describe its use for assessing depth of anesthesia in the operation theater. In this study, we evaluated qCON for assessing sedation compared with Richmond Agitation Sedation Scale (RASS) in patients on a mechanical ventilator in the ICU.
Eighty-seven mechanically ventilated patients aged between 18 and 60 years were investigated over a 12-hour period. They were given a standardized dosage of sedation comprised of a bolus dose of propofol 0.5 mg/kg and fentanyl 1 µg/kg, and then infusions of propofol 2-5 mg/kg/hour and fentanyl 0.5-2 µg/kg/hour. These drug infusions were adjusted to achieve a RASS score between 0 and -3. Using the qCON monitor, the investigator recorded the qCON values and then assessed the RASS score.
A total of 1,218 readings were obtained. After contrasting each qCON value correspondingly with time to each RASS value, we found their correlation to be statistically significant (ρ = 0.288, <0.0001). With the help of receiver operating characteristic (ROC) curves, we were able to differentiate appropriate from inappropriate levels of sedation. A qCON value of 80 had a sensitivity of 72.67% and a specificity of 67.42% (AUC 0.738 with SE 0.021).
qCON can be used for assessing sedation levels in mechanically ventilated critically ill patients.
CTRI/2019/07/020064.
Harsha MS, Bhatia PK, Sharma A, Sethi P. Comparison of Quantium Consciousness Index and Richmond Agitation Sedation Scale in Mechanically Ventilated Critically Ill Patients: An Observational Study. Indian J Crit Care Med 2022;26(4):491-495.
量子意识指数（qCON）是一种基于脑电图（EEG）的指标，目前尚无关于重症监护病房（ICU）镇静的研究，尽管仅有极少研究描述了其在手术室中用于评估麻醉深度的情况。在本研究中，我们在ICU中对使用机械通气的患者，评估了qCON与里士满躁动镇静量表（RASS）相比在评估镇静方面的效果。
在12小时内对87名年龄在18至60岁之间使用机械通气的患者进行了调查。给予他们标准化剂量的镇静药物，包括单次静脉注射异丙酚0.5mg/kg和芬太尼1μg/kg，然后持续输注异丙酚2 - 5mg/（kg·小时）和芬太尼0.5 - 2μg/（kg·小时）。调整这些药物输注量以使RASS评分在0至 - 3之间。使用qCON监测仪，研究人员记录qCON值，然后评估RASS评分。
共获得1218次读数。将每个qCON值与对应的每个RASS值随时间进行对比后，我们发现它们之间的相关性具有统计学意义（ρ = 0.288，P < 0.0001）。借助受试者工作特征（ROC）曲线，我们能够区分合适与不合适的镇静水平。qCON值为80时，灵敏度为72.67%，特异度为67.42%（曲线下面积[AUC]为0.738，标准误[SE]为0.021）。
qCON可用于评估使用机械通气的危重症患者的镇静水平。
CTRI/2019/07/020064。
Harsha MS, Bhatia PK, Sharma A, Sethi P. 机械通气危重症患者中量子意识指数与里士满躁动镇静量表的比较：一项观察性研究。《印度重症监护医学杂志》2022；26(4):491 - 495。
