Liu Yuqing, Chen Xin, Che Yutong, Li Hongli, Zhang Zheyu, Peng Weijun, Yang Jingjing
1Department of Integrated Traditional Chinese & Western Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
2Xiangya School of Medicine, Central South University, Changsha, Hunan, China.
Aging Dis. 2022 Jun 1;13(3):837-851. doi: 10.14336/AD.2021.1119. eCollection 2022 Jun.
Alzheimer's disease (AD) is the most common type of dementia and a serious threat to the health and safety of the elderly population. It has become an emerging public health problem and a major economic and social burden. However, there is currently no effective treatment for AD. Although the mechanism of AD pathogenesis has been investigated substantially, the full range of molecular factors that contribute to its development remain largely unclear. In recent years, accumulating evidence has revealed that long non-coding RNAs (lncRNAs), a type of non-coding RNA longer than 200 nucleotides, play important roles in multiple biological processes involved in AD pathogenesis. With the further exploration of genomics, the role of lncRNA in the pathogenesis of AD has been phenotypically or mechanistically studied. Herein, we systematically review the current knowledge about lncRNAs implicated in AD and elaborate on their main regulatory pathways, which may contribute to the discovery of novel therapeutic targets and drugs for AD.
阿尔茨海默病（AD）是最常见的痴呆类型，对老年人群的健康和安全构成严重威胁。它已成为一个新出现的公共卫生问题以及一项重大的经济和社会负担。然而，目前尚无针对AD的有效治疗方法。尽管对AD发病机制的研究已相当深入，但导致其发展的全部分子因素在很大程度上仍不清楚。近年来，越来越多的证据表明，长链非编码RNA（lncRNAs），一种长度超过200个核苷酸的非编码RNA，在AD发病机制涉及的多个生物学过程中发挥重要作用。随着基因组学的进一步探索，lncRNA在AD发病机制中的作用已从表型或机制方面进行了研究。在此，我们系统地综述了目前关于与AD相关的lncRNAs的知识，并详细阐述了它们的主要调控途径，这可能有助于发现AD的新型治疗靶点和药物。
