Department of Radiology, DongGuan Tungwah Hospital, DongGuan, Guangdong, 523000, People's Republic of China.
Department of Radiology, Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai, Guangdong, 519000, People's Republic of China.
Int J Nanomedicine. 2022 May 26;17:2435-2446. doi: 10.2147/IJN.S357493. eCollection 2022.
Nasopharyngeal carcinoma (NPC) is a common malignant tumor of the head and neck with a high incidence rate worldwide, especially in southern China. Phototheranostics in combination with nanoparticles is an integrated strategy for enabling simultaneous diagnosis, real-time monitoring, and administration of precision therapy for nasopharyngeal carcinoma (NPC). It has shown great potential in the field of cancer diagnosis and treatment owing to its unique noninvasive advantages. Many Chinese and international research teams have applied nano-targeted drugs to optical diagnosis and treatment technology to conduct multimodal imaging and collaborative treatment of NPC, which has become a hot research topic. In this review, we aimed to introduce the recent developments in phototheranostics of NPC based on a nanoplatform. This study aimed to elaborate on the applications of nanoplatform-based optical imaging strategies and treatment modalities, including fluorescence imaging, photoacoustic imaging, Raman spectroscopy imaging, photodynamic therapy, and photothermal therapy. This study is expected to provide a scientific basis for further research and development of NPC diagnosis and treatment.
鼻咽癌（NPC）是一种常见的头颈部恶性肿瘤，全球发病率较高，尤其是在中国南方。光热治疗联合纳米颗粒是一种综合策略，可实现鼻咽癌的同时诊断、实时监测和精准治疗。由于其独特的无创优势，它在癌症诊断和治疗领域显示出巨大的潜力。许多中国和国际研究团队已经将纳米靶向药物应用于光学诊断和治疗技术，对 NPC 进行多模态成像和协同治疗，这已成为一个热门研究课题。在本综述中，我们旨在介绍基于纳米平台的 NPC 光热治疗的最新进展。本研究旨在详细阐述基于纳米平台的光学成像策略和治疗方式的应用，包括荧光成像、光声成像、拉曼光谱成像、光动力治疗和光热治疗。本研究有望为 NPC 的诊断和治疗的进一步研究和开发提供科学依据。
