生活方式干预对循环 miR-375-3p 的变化及内脏和肝脂肪含量的改善：CENTRAL 试验。
Changes in Circulating miR-375-3p and Improvements in Visceral and Hepatic Fat Contents in Response to Lifestyle Interventions: The CENTRAL Trial.
机构信息
Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA.
Core Unit DNA Technologies, Medical Faculty, Leipzig University, Leipzig, Germany.
出版信息
Diabetes Care. 2022 Aug 1;45(8):1911-1913. doi: 10.2337/dc21-2517.
OBJECTIVE
To investigate whether changes in circulating levels of pancreatic islet-related miRNA-375 (miR-375) are related to improved visceral and intrahepatic fat accumulation.
RESEARCH DESIGN AND METHODS
This study included adults with abdominal obesity from an 18-month weight loss lifestyle intervention trial. Circulating miR-375-3p was measured at baseline and 18 months. MRI was performed (n = 139) to assess 18-month changes in abdominal and intrahepatic fat depots.
RESULTS
Circulating miR-375-3p was related to fasting insulin and insulin resistance in participants with prediabetes. After the interventions, there was a significant increase of miR-375-3p (P < 0.001). Greater increase in miR-375-3p was associated with greater reductions of visceral (P = 0.024) and deep subcutaneous (P < 0.001) adipose tissues and intrahepatic fat content (P = 0.012).
CONCLUSIONS
Increases in circulating miR-375-3p were associated with visceral and intrahepatic fat reduction. Changes in circulating pancreatic islet-related miR-375-3p may be linked to improved diabetogenic fat depots during weight loss lifestyle interventions.
目的
研究循环胰岛相关 miRNA-375（miR-375）水平的变化是否与内脏和肝内脂肪堆积的改善有关。
研究设计和方法
本研究纳入了来自为期 18 个月的减肥生活方式干预试验的腹型肥胖成年人。在基线和 18 个月时测量循环 miR-375-3p。进行 MRI 检查（n = 139）以评估腹部和肝内脂肪蓄积的 18 个月变化。
结果
循环 miR-375-3p与糖尿病前期参与者的空腹胰岛素和胰岛素抵抗有关。干预后，miR-375-3p 显著增加（P < 0.001）。miR-375-3p 增加幅度越大，内脏（P = 0.024）和深皮下（P < 0.001）脂肪组织以及肝内脂肪含量的减少幅度越大（P = 0.012）。
结论
循环 miR-375-3p 的增加与内脏和肝内脂肪减少有关。循环胰岛相关 miR-375-3p 的变化可能与减肥生活方式干预期间改善的糖尿病相关脂肪蓄积有关。
Zotero 插件