运动对晚期癌症患者功能能力的影响：一项随机对照试验的荟萃分析。
Effect of exercise on functional capacity in patients with advanced cancer: A meta-analysis of randomized controlled trials.
机构信息
Section of Oncology, Department of Medicine, University of Verona School of Medicine and Verona University Hospital Trust, Verona, Italy; Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Biostatistical Unit - Clinical Trials Center IRCCS Istituto Nazionale Tumori Regina Elena, U.O. di Biostatistica e Bioinformatica, Rome, Italy.
出版信息
Crit Rev Oncol Hematol. 2022 Jul;175:103726. doi: 10.1016/j.critrevonc.2022.103726. Epub 2022 Jun 2.
PURPOSE
To determine the impact of exercise on functional capacity, measured through the "Six minutes walking test" (6MWT) in patients with advanced cancer stage.
METHODS
Systematic research on PubMed, Cochrane Library, and SportDiscus was conducted. Randomized controlled trials were eligible if they examined the effect of exercise on 6MWT.
RESULTS
Overall, a total of ten trials were included in the primary analysis. Compared to the controls, the exercise intervention was associated with an increase in functional capacity (+20.86 m; CI: -5.90 to 47.72, p = 0.12) although not reaching the statistical significance. Sensitivity analysis revealed an improvement for studies proposing a supervised exercise intervention towards the statistical significance. Few adverse events were associated with exercise training, and the median withdrawals rate was 17%.
CONCLUSIONS
Exercise may have a beneficial role on functional capacity in patients with advanced cancer, especially if supervised.
目的
通过“六分钟步行测试”（6MWT）评估，确定运动对晚期癌症患者的功能能力的影响。
方法
对 PubMed、Cochrane Library 和 SportDiscus 进行系统检索。纳入评估运动对 6MWT 影响的随机对照试验。
结果
共有 10 项试验纳入主要分析。与对照组相比，运动干预与功能能力的提高相关（+20.86 m；95%CI：-5.90 至 47.72，p = 0.12），但未达到统计学意义。敏感性分析显示，提出监督运动干预的研究结果具有统计学意义。运动训练相关的不良事件较少，中位退出率为 17%。
结论
运动可能对晚期癌症患者的功能能力有有益作用，尤其是监督下的运动。
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