Department of Biochemistry, University of Delhi, Delhi, India.
Department of Chemistry, Kirori Mal College, University of Delhi, Delhi, India.
Tissue Eng Regen Med. 2022 Oct;19(5):927-960. doi: 10.1007/s13770-022-00459-z. Epub 2022 Jun 4.
Tissue engineering is a research domain that deals with the growth of various kinds of tissues with the help of synthetic composites. With the culmination of nanotechnology and bioengineering, tissue engineering has emerged as an exciting domain. Recent literature describes its various applications in biomedical and biological sciences, such as facilitating the growth of tissue and organs, gene delivery, biosensor-based detection, etc. It deals with the development of biomimetics to repair, restore, maintain and amplify or strengthen several biological functions at the level of tissue and organs. Herein, the synthesis of nanocomposites based on polymers, along with their classification as conductive hydrogels and bioscaffolds, is comprehensively discussed. Furthermore, their implementation in numerous tissue engineering and regenerative medicine applications is also described. The limitations of tissue engineering are also discussed here. The present review highlights and summarizes the latest progress in the tissue engineering domain directed at functionalized nanomaterials.
组织工程学是一个研究领域，它借助于合成复合材料来促进各种组织的生长。随着纳米技术和生物工程学的发展，组织工程学已经成为一个令人兴奋的领域。最近的文献描述了它在生物医学和生物学中的各种应用，例如促进组织和器官的生长、基因传递、基于生物传感器的检测等。它涉及仿生学的发展，以修复、恢复、维持和放大或增强组织和器官水平的多种生物学功能。本文全面讨论了基于聚合物的纳米复合材料的合成，以及它们作为导电水凝胶和生物支架的分类。此外，还描述了它们在许多组织工程和再生医学应用中的应用。本文还讨论了组织工程学的局限性。本综述重点总结了组织工程领域在功能化纳米材料方面的最新进展。
