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头孢哌酮和妥布霉素单独及联合应用的药代动力学

Pharmacokinetics of cefoperazone and tobramycin alone and in combination.

作者信息

Guglielmo B J, Flaherty J F, Woods T M, LaFollette G, Gambertoglio J G

出版信息

Antimicrob Agents Chemother. 1987 Feb;31(2):264-6. doi: 10.1128/AAC.31.2.264.

DOI:10.1128/AAC.31.2.264
PMID:3566252
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC174703/
Abstract

Certain beta-lactams have been shown to increase the clearance of tobramycin. We evaluated the pharmacokinetics of cefoperazone and tobramycin, alone and in combination, in healthy volunteers. No significant alteration in pharmacokinetic behavior was noted for cefoperazone or tobramycin alone or in combination.

摘要

已证实某些β-内酰胺类药物可增加妥布霉素的清除率。我们评估了头孢哌酮和妥布霉素单独及联合应用于健康志愿者时的药代动力学。单独使用或联合使用头孢哌酮或妥布霉素时，未观察到药代动力学行为有显著改变。

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Pharmacokinetics of cefoperazone and tobramycin alone and in combination.头孢哌酮和妥布霉素单独及联合应用的药代动力学
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本文引用的文献

1
Antibiotic synergism and antimicrobial combinations in clinical infections.临床感染中的抗生素协同作用及抗菌药物联合应用
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Interactions of moxalactam and tobramycin in normal volunteers and in patients with impaired renal function.
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Synergism at clinically attainable concentrations of aminoglycoside and beta-lactam antibiotics.氨基糖苷类抗生素与β-内酰胺类抗生素在临床可达到浓度下的协同作用。
Antimicrob Agents Chemother. 1984 Oct;26(4):535-8. doi: 10.1128/AAC.26.4.535.
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Inactivation of gentamicin by penicillins in patients with renal failure.肾衰竭患者中青霉素对庆大霉素的灭活作用。
Antimicrob Agents Chemother. 1976 Jun;9(6):1004-11. doi: 10.1128/AAC.9.6.1004.
5
Effect of time and concentration upon interaction between gentamicin, tobramycin, Netilmicin, or amikacin and carbenicillin or ticarcillin.时间和浓度对庆大霉素、妥布霉素、奈替米星或阿米卡星与羧苄西林或替卡西林之间相互作用的影响。
Antimicrob Agents Chemother. 1979 Apr;15(4):592-6. doi: 10.1128/AAC.15.4.592.
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Significance of antimicrobial synergism for the outcome of gram negative sepsis.
Am J Med Sci. 1977 Mar-Apr;273(2):157-67. doi: 10.1097/00000441-197703000-00005.