头孢哌酮和妥布霉素单独及联合应用的药代动力学
Pharmacokinetics of cefoperazone and tobramycin alone and in combination.
作者信息
Guglielmo B J, Flaherty J F, Woods T M, LaFollette G, Gambertoglio J G
出版信息
Antimicrob Agents Chemother. 1987 Feb;31(2):264-6. doi: 10.1128/AAC.31.2.264.
Abstract
Certain beta-lactams have been shown to increase the clearance of tobramycin. We evaluated the pharmacokinetics of cefoperazone and tobramycin, alone and in combination, in healthy volunteers. No significant alteration in pharmacokinetic behavior was noted for cefoperazone or tobramycin alone or in combination.
摘要
已证实某些β-内酰胺类药物可增加妥布霉素的清除率。我们评估了头孢哌酮和妥布霉素单独及联合应用于健康志愿者时的药代动力学。单独使用或联合使用头孢哌酮或妥布霉素时，未观察到药代动力学行为有显著改变。
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