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Comparisons of in vivo and in vitro photosensitivities and DNA repair in fibroblast and keratinocyte cells.

作者信息

Machino H, Shiraishi S, Miki Y

出版信息

Arch Dermatol Res. 1986;279(2):125-9. doi: 10.1007/BF00417533.

DOI:10.1007/BF00417533
PMID:3566336
Abstract

Minimal erythema dose of ultraviolet light correlated significantly with the UV-sensitivity of fibroblast cells from 5 patients with xeroderma pigmentosum, 13 patients with keratinocytic neoplasms of the skin, and 21 control subjects, but not with that of cells from 6 patients with photosensitive dermatitis. In unscheduled DNA synthesis after UV irradiation, the number of grains per nucleus was much less in keratinocytes than in fibroblasts, but the relative dose-response relationship was similar. This indicates that keratinocytes can also be used in vitro UV-sensitivity studies.

摘要

相似文献

1
Comparisons of in vivo and in vitro photosensitivities and DNA repair in fibroblast and keratinocyte cells.
Arch Dermatol Res. 1986;279(2):125-9. doi: 10.1007/BF00417533.
2
Defect in UV-induced unscheduled DNA synthesis in cultured epidermal keratinocytes from xeroderma pigmentosum.着色性干皮病患者培养的表皮角质形成细胞中紫外线诱导的非程序性DNA合成缺陷。
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3
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Xeroderma pigmentosum epidermal cells with normal UV-induced thymidine incorporation.具有正常紫外线诱导胸苷掺入的着色性干皮病表皮细胞。
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A human subject with a new defect in repair of ultraviolet damage.一名在紫外线损伤修复方面存在新缺陷的人类受试者。
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Reduced levels of UV-induced unscheduled DNA synthesis in epidermal keratinocytes of patients with xeroderma pigmentosum and correlation with development of skin neoplasms.着色性干皮病患者表皮角质形成细胞中紫外线诱导的非程序性DNA合成水平降低及其与皮肤肿瘤发生的相关性。
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Differential behaviors toward ultraviolet A and B radiation of fibroblasts and keratinocytes from normal and DNA-repair-deficient patients.正常和DNA修复缺陷患者的成纤维细胞和角质形成细胞对紫外线A和B辐射的差异行为。
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Colony-forming ability of ultraviolet-irradiated xeroderma pigmentosum fibroblasts from different DNA repair complementation groups.来自不同DNA修复互补组的紫外线照射的着色性干皮病成纤维细胞的集落形成能力。
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Cockayne's syndrome fibroblasts have increased sensitivity to ultraviolet light but normal rates of unscheduled DNA synthesis.科凯恩综合征成纤维细胞对紫外线的敏感性增加，但非定时DNA合成速率正常。
J Invest Dermatol. 1978 May;70(5):237-9. doi: 10.1111/1523-1747.ep12541383.

本文引用的文献

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DNA repair following ultraviolet and N-ethyl-N-nitrosourea treatment of cells cultured from human fetal brain, intestine, kidney, liver, and skin.对源自人类胎儿脑、肠、肾、肝和皮肤的培养细胞进行紫外线和N-乙基-N-亚硝基脲处理后的DNA修复
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Xeroderma pigmentosum epidermal cells with normal UV-induced thymidine incorporation.具有正常紫外线诱导胸苷掺入的着色性干皮病表皮细胞。
J Invest Dermatol. 1972 Nov;59(5):402-8. doi: 10.1111/1523-1747.ep12627528.
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Non-melanoma skin cancer among Caucasians in four areas of the United States.
Cancer. 1974 Oct;34(4):1333-8. doi: 10.1002/1097-0142(197410)34:4<1333::aid-cncr2820340447>3.0.co;2-a.
8
Comparative studies of host-cell reactivation, colony forming ability and excision repair after UV irradiation of xeroderma pigmentosum, normal human and some other mammalian cells.着色性干皮病患者细胞、正常人细胞及其他一些哺乳动物细胞经紫外线照射后宿主细胞复活、集落形成能力及切除修复的比较研究
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Repair of ultraviolet light damage in a variety of human fibroblast cell strains.多种人类成纤维细胞株中紫外线损伤的修复
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