Lanari Daniela, Zadra Claudia, Negro Francesca, Njem Rima, Marcotullio Maria Carla
Dipartimento di Scienze Farmaceutiche, Università degli Studi di Perugia, Via Fabretti, 48-06123, Perugia, Italy.
Heliyon. 2022 May 24;8(5):e09531. doi: 10.1016/j.heliyon.2022.e09531. eCollection 2022 May.
Natural deep eutectic solvents (NADES) have emerged as green extracting solvents in recent years. In this study, a variety of choline chloride (ChCl)-based natural deep eutectic solvents (NADES) were used as co-solvents for the hydrodistillation of nutmeg with the aim to obtain essential oil (EO) in higher yield and with a lower content of toxic phenylpropenoids (e.g. myristicin and safrole). The influence of ChCl-based NADES as additives in the hydrodistillation process was studied. The results showed that NADES additives improved the yield of the extracted essential oil and influenced its composition leading to a decrease in toxic phenylpropenoids. Best results were achieved by using ChCl-CA NADES ultrasound-assisted pretreatment coupled with traditional 2 h Clevenger hydrodistillation that increased the yield of the EO from 0.98% (traditional) to 1.41% and a decrease of the phenylpropenoids amount in the essential oil.
近年来，天然深共熔溶剂（NADES）已成为绿色萃取溶剂。在本研究中，多种基于氯化胆碱（ChCl）的天然深共熔溶剂（NADES）被用作肉豆蔻水蒸馏的共溶剂，目的是获得更高产率且有毒苯丙素类化合物（如肉豆蔻醚和黄樟素）含量更低的精油（EO）。研究了基于ChCl的NADES作为添加剂在水蒸馏过程中的影响。结果表明，NADES添加剂提高了萃取精油的产率并影响其成分，导致有毒苯丙素类化合物减少。通过使用ChCl-CA NADES超声辅助预处理结合传统的2小时克莱文杰水蒸馏获得了最佳结果，该方法将精油产率从0.98%（传统方法）提高到1.41%，并减少了精油中苯丙素类化合物的含量。
