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磷脂与凝血蛋白的相互作用:生物电子应用的潜在候选物

Interaction of a Phospholipid and a Coagulating Protein: Potential Candidate for Bioelectronic Applications.

作者信息

Paul Ripa, Banik Hritinava, Alzaid Meshal, Bhattacharjee Debajyoti, Hussain Syed Arshad

机构信息

Thin Film and Nanoscience Laboratory, Department of Physics, Tripura University, Suryamaninagar 799022, Tripura, India.

Physics Department, College of Science, Jouf University, P.O. Box 2014, Sakaka, Al-Jouf 75471, Saudi Arabia.

出版信息

ACS Omega. 2022 May 17;7(21):17583-17592. doi: 10.1021/acsomega.1c07395. eCollection 2022 May 31.

DOI:10.1021/acsomega.1c07395
PMID:35664573
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9161252/
Abstract

In the present communication, we have investigated the interaction between a biomembrane component 1,2-dioleoyl--glycero-3-phosphocholine (DOPC) and a coagulating protein protamine sulfate (PS) using the Langmuir-Blodgett (LB) technique. The π- isotherm, π- characteristics, and analysis of isotherm curves suggested that PS strongly interacted with DOPC, affecting the fluidity of the DOPC layer. Electrical characterization indicates that PS as well as the PS-DOPC film showed resistive switching behavior suitable for Write Once Read Many (WORM) memory application. Trap-controlled space charge-limited conduction (SCLC) was the key mechanism behind such observed switching. The presence of DOPC affected the SCLC process, leading to lowering of threshold voltage ( ), which is advantageous in terms of lower power consumption.

摘要

在本通讯中,我们使用朗缪尔-布洛杰特(LB)技术研究了生物膜成分1,2-二油酰基-sn-甘油-3-磷酸胆碱(DOPC)与凝血蛋白硫酸鱼精蛋白(PS)之间的相互作用。π等温线、π特性以及等温线曲线分析表明,PS与DOPC强烈相互作用,影响了DOPC层的流动性。电学特性表明,PS以及PS-DOPC膜表现出适合一次写入多次读取(WORM)存储器应用的电阻切换行为。陷阱控制的空间电荷限制传导(SCLC)是这种观察到的切换背后的关键机制。DOPC的存在影响了SCLC过程,导致阈值电压( )降低,这在较低功耗方面是有利的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78af/9161252/74d865ff74e8/ao1c07395_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78af/9161252/b1e76d7b2d85/ao1c07395_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78af/9161252/ea615e93ec94/ao1c07395_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78af/9161252/a33f7afbf609/ao1c07395_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78af/9161252/74d865ff74e8/ao1c07395_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78af/9161252/b1e76d7b2d85/ao1c07395_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78af/9161252/ea615e93ec94/ao1c07395_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78af/9161252/a33f7afbf609/ao1c07395_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78af/9161252/74d865ff74e8/ao1c07395_0005.jpg

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