Liao Yi, Liu Lingling, Zhou Hua, Fang Feng, Liu Xinglou
Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Pediatr. 2022 May 19;10:857900. doi: 10.3389/fped.2022.857900. eCollection 2022.
is widely distributed in the environment and food and is considered a non-pathogenic bacterium for both humans and animals. To our knowledge, only a few cases of infection in humans and ruminants have been reported. Moreover, there has been no report on human meningoencephalitis. Here, we report a case of severe refractory meningoencephalitis in a three-year-old boy after infection with . The child's first symptoms were a runny nose, high fever, and rashes, which quickly progressed to unconsciousness and convulsions. The initial analysis of cerebral spinal fluid revealed remarkably elevated protein levels and increased white blood cells count. The blood culture of the patient in the early stage was positive for In addition, his brain imaging tests were observed dynamically, and the result showed a speedy progression from multiple intracranial abnormal signals to hydrocephalus and interstitial cerebral edema. After receiving antibiotics and symptomatic treatment for nearly 3 months, the patient's condition improved markedly. However, he still had residual complications such as hydrocephalus. Although is considered harmless, it can still cause disease in humans, even severe meningoencephalitis, with rapid progression and poor prognosis. Early discovery, diagnosis, and treatment are necessary to elevate the survival rate and life quality of those patients. Antibiotics should be used with sufficient duration and dosage. Cephalosporins are not suitable for the treatment of meningoencephalitis and penicillin antibiotics are preferred for children. The presentation of this case will help to expand our knowledge of infections and provide a potential candidate for pathogens causing severe childhood central nervous system infection.
广泛分布于环境和食物中，被认为对人类和动物均无致病性。据我们所知，仅报告了少数人类和反刍动物感染的病例。此外，尚无人类脑膜脑炎的报告。在此，我们报告一例三岁男孩感染后发生的严重难治性脑膜脑炎病例。患儿最初症状为流鼻涕、高烧和皮疹，很快发展为昏迷和惊厥。脑脊液初步分析显示蛋白水平显著升高，白细胞计数增加。患者早期血培养对 呈阳性。此外，对其脑部影像学检查进行动态观察，结果显示从多个颅内异常信号迅速发展为脑积水和间质性脑水肿。在接受近3个月的抗生素和对症治疗后，患者病情明显改善。然而，他仍有脑积水等残留并发症。尽管 被认为无害，但它仍可导致人类发病，甚至是严重的脑膜脑炎，病情进展迅速且预后不良。早期发现、诊断和治疗对于提高这些患者的生存率和生活质量至关重要。抗生素应使用足够的疗程和剂量。头孢菌素不适合治疗 脑膜脑炎，儿童首选青霉素类抗生素。该病例的呈现将有助于扩展我们对 感染的认识，并为导致儿童严重中枢神经系统感染的病原体提供一个潜在候选者。
